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Title: IGF-I and IGF binding proteins in diabetes-related kidney growth.
Austin Authors: Bach, Leon A
Affiliation: Endocrine Unit, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 1-Mar-1992
Publication information: Growth Regulation; 2(1): 30-9
Abstract: The kidney is a site of insulin-like growth factor I (IGF-I) production and IGF-I mediates effects on kidney growth and function. Diabetes is associated with kidney growth in man and the rat and, in the latter, commences within 48 h of induction of diabetes. Levels of kidney IGF-I are increased during the first 2-3 days of diabetes and this is at least partially due to increased production. Additionally, IGF-I binding is increased in diabetic rat kidney, due to increased binding to the IGF-I receptor and induction of proximal tubular binding protein expression. These changes are attenuated in prepubertal rats suggesting hormonal regulation. Further studies suggest that the changes are partly GH-dependent but independent of direct sex steroid effects. As kidney growth has been implicated in the subsequent development of diabetic nephropathy, further exploration of the close association between diabetes-related kidney growth and IGF-I accumulation may lead to an improved understanding of this complication.
Gov't Doc #: 1283098
Type: Journal Article
Subjects: Animals
Carrier Proteins.physiology
Cell Division.physiology
Diabetes Mellitus.pathology.physiopathology
Diabetic Nephropathies.physiopathology
Insulin-Like Growth Factor Binding Proteins
Insulin-Like Growth Factor I.physiology
Kidney.growth & development.pathology.physiology
Appears in Collections:Journal articles

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