Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9511
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dc.contributor.authorSiritho, Sasitornen
dc.contributor.authorThrift, Amanda Gen
dc.contributor.authorMcNeil, John Jen
dc.contributor.authorYou, Roger Xen
dc.contributor.authorDavis, Stephen Men
dc.contributor.authorDonnan, Geoffrey Aen
dc.date.accessioned2015-05-15T22:37:55Z
dc.date.available2015-05-15T22:37:55Z
dc.date.issued2003-06-12en
dc.identifier.citationStroke; A Journal of Cerebral Circulation 2003; 34(7): 1575-80en
dc.identifier.govdoc12805499en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/9511en
dc.description.abstractUse of oral contraceptives has increased, and there is uncertainty about the stroke risk associated with their use. Our aim was to investigate this issue.Using case-control techniques, we identified consecutive women with ischemic stroke from 4 Melbourne hospitals. All patients were between 15 and 55 years of age and had no prior stroke. Neighborhood-based control subjects were individually age-matched (+/-5 years) and geographically matched to subject cases. A questionnaire administered to participants elicited information about prior exposure to various potential risk factors, including the oral contraceptive pill (OCP).We included 234 cases and 234 controls (mean age, 42 years). Compared with noncurrent use, current use of the OCP, in doses of <or=50 microg estrogen, was not associated with an increased risk of ischemic stroke (odds ratio [OR] 1.76; 95% CI, 0.86 to 3.61; P=0.124). Factors associated with an increased risk of ischemic stroke were a history of hypertension (OR, 2.18; 95% CI, 1.22 to 3.91), transient ischemic attack (OR, 8.17; 95% CI, 1.69 to 39.6), previous myocardial infarction (OR, 5.64; 95% CI, 1.04 to 30.61), and diabetes mellitus (OR, 5.42; 95% CI, 1.42 to 20.75); family history of stroke (OR, 2.22; 95% CI, 1.12 to 4.43); and smoking >20 cigarettes per day (OR, 3.68; 95% CI, 1.22 to 11.09).There was no evidence for an association between ischemic stroke and use of the OCP in low doses (<or=50 microg estrogen) in young Australian women. Other modifiable risk factors such as hypertension, diabetes mellitus, and smoking are important.en
dc.language.isoenen
dc.subject.otherAdolescenten
dc.subject.otherAdulten
dc.subject.otherAustralia.epidemiologyen
dc.subject.otherBrain Ischemia.chemically induced.epidemiologyen
dc.subject.otherCase-Control Studiesen
dc.subject.otherComorbidityen
dc.subject.otherContraceptives, Oral.adverse effectsen
dc.subject.otherDiet.statistics & numerical dataen
dc.subject.otherEstrogens.adverse effectsen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherMiddle Ageden
dc.subject.otherOdds Ratioen
dc.subject.otherRisk Assessmenten
dc.subject.otherRisk Factorsen
dc.subject.otherSmoking.epidemiologyen
dc.subject.otherStroke.chemically induced.epidemiologyen
dc.titleRisk of ischemic stroke among users of the oral contraceptive pill: The Melbourne Risk Factor Study (MERFS) Group.en
dc.typeJournal Articleen
dc.identifier.journaltitleStrokeen
dc.identifier.affiliationNational Stroke Research Institute, Austin & Repatriation Medical Centre, West Heidelberg, Australiaen
dc.identifier.doi10.1161/01.STR.0000077925.16041.6Ben
dc.description.pages1575-80en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/12805499en
dc.contributor.corpauthorMelbourne Risk Factor Study (MERFS) Groupen
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.languageiso639-1en-
item.fulltextNo Fulltext-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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