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Title: | Effect of amlodipine pretreatment on ischaemia-reperfusion-induced increase in cardiac endothelin-1 binding site density. | Austin Authors: | Nayler, W G;Ou, R C;Gu, X H;Casley, David J | Affiliation: | Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia | Issue Date: | 1-Sep-1992 | Publication information: | Journal of Cardiovascular Pharmacology; 20(3): 416-20 | Abstract: | Endothelin-1 (ET-1) may be implicated in the pathophysiology of myocardial ischaemia. To determine whether the long-acting calcium antagonist amlodipine attenuates the ischaemia- and reperfusion-induced increase in cardiac ET-1 binding sites, hearts from rats pretreated with amlodipine (0.25 or 0.5 mg/kg) 2 or 5 h before they were killed were made ischaemic for 20 or 40 min, reperfused, and subfractionated. Twenty- and 40-min ischaemia caused a time-dependent increase in ET-1 binding site density (Bmax) identified with [125I]ET-1. Amlodipine pretreatment attenuated this increase in a time- and dose-dependent manner. 0.25 and 0.5 mg/kg amlodipine also suppressed the reperfusion-induced increase in [125I]ET-1 binding site density, even when the 0.5-mg/kg pretreatment series reperfusion was administered after 40-min ischaemia. | Gov't Doc #: | 1279286 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/9506 | Journal: | Journal of Cardiovascular Pharmacology | URL: | https://pubmed.ncbi.nlm.nih.gov/1279286 | Type: | Journal Article | Subjects: | Amlodipine.pharmacology Animals Calcium Channel Blockers.pharmacology Endothelins.metabolism Female In Vitro Techniques Myocardial Reperfusion Injury.metabolism Rats Rats, Inbred WKY Receptors, Endothelin.drug effects.metabolism |
Appears in Collections: | Journal articles |
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