Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9442
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dc.contributor.authorDodd, Seetalen
dc.contributor.authorBoulton, David W.en
dc.contributor.authorBurrows, Graham D.en
dc.contributor.authorDe Vane, C. Lindsayen
dc.contributor.authorNorman, Trevor Ren
dc.date.accessioned2015-05-15T22:32:25Z
dc.date.available2015-05-15T22:32:25Z
dc.date.issued2001-10-01en
dc.identifier.citationHuman Psychopharmacology; 16(7): 541-544en
dc.identifier.govdoc12404550en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9442en
dc.description.abstractThe metabolism of mirtazapine enantiomers was investigated in vitro using human lymphoblast microsomes transfected with human cDNA to overexpress either CYP1A2, CYP2C9, CYP2C19, CYP2D6 or CYP3A4 and assayed for mirtazapine enantiomers using a validated chiral method of high-performance liquid chromatography. (+)-Mirtazapine was extensively metabolised by CYP2D6 (K(m) = 9.3 +/- 3.3 &mgr;mol/l, V(max) = 40.9 +/- 7.9 &mgr;mol/h/mg, intrinsic clearance = 4.41 l/h/mg). CYP1A2 and CYP3A4 showed low metabolic activity towards (+)-mirtazapine and (-)-mirtazapine respectively. Neither CYP2C9 nor CYP2C19 appeared to be involved in the metabolism of the enantiomers of mirtazapine. Copyright 2001 John Wiley & Sons, Ltd.en
dc.language.isoenen
dc.titleIn vitro metabolism of mirtazapine enantiomers by human cytochrome P450 enzymes.en
dc.typeJournal Articleen
dc.identifier.journaltitleHuman psychopharmacologyen
dc.identifier.affiliationDepartment of Psychiatry, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, Victoria 3084, Australiaen
dc.identifier.doi10.1002/hup.328en
dc.description.pages541-544en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/12404550en
dc.type.austinJournal Articleen
local.name.researcherNorman, Trevor R
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptPsychiatry (University of Melbourne)-
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