Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9356
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dc.contributor.authorShulkes, Arthuren
dc.contributor.authorBaldwin, Graham Sen
dc.date.accessioned2015-05-15T22:25:23Z
dc.date.available2015-05-15T22:25:23Z
dc.date.issued2001en
dc.identifier.citationScandinavian Journal of Clinical and Laboratory Investigation. Supplementum; 234(): 123-8en
dc.identifier.govdoc11713973en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/9356en
dc.description.abstractThe regulation and extent of progastrin processing has assumed greater importance with the realisation that progastrin and its processing intermediates have functions quite separate from the biosynthetic end product gastrin-amide. The pattern of processing products generated are organ and disease specific with amidated forms predominating in the stomach and non-amidated forms being more important in colorectal carcinoma. In the stomach, non amidated gastrins sustains the acid stimulatory effect of gastrin amide on gastric acidity. The proliferation of colorectal carcinomas and cell lines are stimulated by nonamidated gastrins presumably by an autocrine regulatory loop acting through distinct receptors. The potential role of non-amidated gastrins as therapeutic targets will remain uncertain until the nature of the receptors are determined and specific antagonists developed.en
dc.language.isoenen
dc.subject.otherAmides.chemistryen
dc.subject.otherAnimalsen
dc.subject.otherColon.metabolismen
dc.subject.otherColorectal Neoplasms.metabolismen
dc.subject.otherGastrins.blood.chemistry.metabolismen
dc.subject.otherHumansen
dc.subject.otherProtein Precursors.chemistry.metabolismen
dc.subject.otherProtein Processing, Post-Translationalen
dc.subject.otherReceptors, Cholecystokinin.metabolismen
dc.subject.otherStomach.metabolismen
dc.titleBiology and pathology of non-amidated gastrins.en
dc.typeJournal Articleen
dc.identifier.journaltitleScandinavian journal of clinical and laboratory investigation. Supplementumen
dc.identifier.affiliationDepartment of Surgery, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australiaen
dc.description.pages123-8en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/11713973en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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