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Title: Biology and pathology of non-amidated gastrins.
Austin Authors: Shulkes, Arthur;Baldwin, Graham S
Affiliation: Department of Surgery, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia
Issue Date: 2001
Publication information: Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum; 234(): 123-8
Abstract: The regulation and extent of progastrin processing has assumed greater importance with the realisation that progastrin and its processing intermediates have functions quite separate from the biosynthetic end product gastrin-amide. The pattern of processing products generated are organ and disease specific with amidated forms predominating in the stomach and non-amidated forms being more important in colorectal carcinoma. In the stomach, non amidated gastrins sustains the acid stimulatory effect of gastrin amide on gastric acidity. The proliferation of colorectal carcinomas and cell lines are stimulated by nonamidated gastrins presumably by an autocrine regulatory loop acting through distinct receptors. The potential role of non-amidated gastrins as therapeutic targets will remain uncertain until the nature of the receptors are determined and specific antagonists developed.
Gov't Doc #: 11713973
Journal: Scandinavian journal of clinical and laboratory investigation. Supplementum
Type: Journal Article
Subjects: Amides.chemistry
Colorectal Neoplasms.metabolism
Protein Precursors.chemistry.metabolism
Protein Processing, Post-Translational
Receptors, Cholecystokinin.metabolism
Appears in Collections:Journal articles

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