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Title: Role of angiotensin II in tubulointerstitial injury.
Austin Authors: Cao, Zemin;Cooper, Mark E
Affiliation: Department of Medicine, University of Melbourne, Austin, Australia
Issue Date: 1-Nov-2001
Publication information: Seminars in Nephrology; 21(6): 554-62
Abstract: The renin angiotensin system (RAS) has been implicated in tubulointerstitial injury in a range of clinical and experimental settings. Angiotensin II, the major effector molecule of the RAS, in addition to its effects on systemic blood pressure and intrarenal hemodynamics, also acts as a local hormone and growth factor to modulate renal function and pathology. There is increasing evidence for a pivotal role of this hormone in influencing renal tubular and interstitial function and structure including regulation of multiple cytokines and chemokines, promoting infiltration of monocytes/macrophages, promoting cellular proliferation, and inducing apoptosis. Pathologic actions of angiotensin II lead to tubulointerstitial fibrosis and inflammation via a range of cytokines and chemokines including transforming growth factor (TNF)-beta1, osteopontin, tumor necrosis factor (TNF)-alpha, secreted protein acidic and rich in cysteine (SPARC), and RANTES (regulated on activation normal T-cell expression and secreted). Blockade of production of angiotensin II by an angiotensin-converting enzyme (ACE) inhibitor or angiotensin II receptor antagonism with an angiotensin type 1 receptor antagonist has been shown to attenuate tubulointerstitial injury and reduce expression of cytokines and matrix proteins. The role of angiotensin II in tubulointerstitial fibrosis and inflammation is addressed in this article.
Gov't Doc #: 11709803
Journal: Seminars in nephrology
Type: Journal Article
Subjects: Angiotensin II.physiology
Chemokine CCL5.physiology
Kidney Tubules.physiology
NF-kappa B.physiology
Nephritis, Interstitial.metabolism.pathology
Renin-Angiotensin System.physiology
Transforming Growth Factor beta.physiology
Transforming Growth Factor beta1
Tumor Necrosis Factor-alpha.physiology
Appears in Collections:Journal articles

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