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Title: Vasopressin receptor antagonism--a therapeutic option in heart failure and hypertension.
Austin Authors: Burrell, Louise M ;Risvanis, John;Johnston, Colin I;Naitoh, M;Balding, Leanne C
Affiliation: Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia
Issue Date: 1-Mar-2000
Publication information: Experimental Physiology; 85 Spec No(): 259S-265S
Abstract: The precise role of vasopressin in the pathophysiology of cardiovascular disease is controversial, but this peptide hormone is important for several reasons. Firstly, circulating concentrations of vasopressin are elevated in heart failure and some forms of hypertension. Secondly, there is evidence that vasopressin is synthesized not only in the hypophysial-pituitary axis but also in peripheral tissues including the heart where it acts as a paracrine hormone. Thirdly, vasopressin has vasoconstrictor, mitogenic, hyperplastic and renal fluid retaining properties which, by analogy with angiotensin II, may have deleterious effects when present in chronic excess. Finally, the availability of orally active non-peptide vasopressin receptor antagonists allows vasopressin receptor antagonism to be considered as a therapeutic option in cardiovascular disease.
Gov't Doc #: 10795930
Journal: Experimental physiology
Type: Journal Article
Subjects: Antidiuretic Hormone Receptor Antagonists
Benzazepines.therapeutic use
Heart Failure.drug therapy.physiopathology
Hypertension.drug therapy.physiopathology
Morpholines.therapeutic use
Receptors, Vasopressin.physiology
Spiro Compounds.therapeutic use
Appears in Collections:Journal articles

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