Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9225
Full metadata record
DC FieldValueLanguage
dc.contributor.authorBurrell, Louise Men
dc.contributor.authorRisvanis, Johnen
dc.contributor.authorJohnston, Colin Ien
dc.contributor.authorNaitoh, Men
dc.contributor.authorBalding, Leanne Cen
dc.date.accessioned2015-05-15T22:14:10Z
dc.date.available2015-05-15T22:14:10Z
dc.date.issued2000-03-01en
dc.identifier.citationExperimental Physiology; 85 Spec No(): 259S-265Sen
dc.identifier.govdoc10795930en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9225en
dc.description.abstractThe precise role of vasopressin in the pathophysiology of cardiovascular disease is controversial, but this peptide hormone is important for several reasons. Firstly, circulating concentrations of vasopressin are elevated in heart failure and some forms of hypertension. Secondly, there is evidence that vasopressin is synthesized not only in the hypophysial-pituitary axis but also in peripheral tissues including the heart where it acts as a paracrine hormone. Thirdly, vasopressin has vasoconstrictor, mitogenic, hyperplastic and renal fluid retaining properties which, by analogy with angiotensin II, may have deleterious effects when present in chronic excess. Finally, the availability of orally active non-peptide vasopressin receptor antagonists allows vasopressin receptor antagonism to be considered as a therapeutic option in cardiovascular disease.en
dc.language.isoenen
dc.subject.otherAntidiuretic Hormone Receptor Antagonistsen
dc.subject.otherBenzazepines.therapeutic useen
dc.subject.otherHeart Failure.drug therapy.physiopathologyen
dc.subject.otherHumansen
dc.subject.otherHypertension.drug therapy.physiopathologyen
dc.subject.otherMorpholines.therapeutic useen
dc.subject.otherReceptors, Vasopressin.physiologyen
dc.subject.otherSpiro Compounds.therapeutic useen
dc.titleVasopressin receptor antagonism--a therapeutic option in heart failure and hypertension.en
dc.typeJournal Articleen
dc.identifier.journaltitleExperimental physiologyen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australiaen
dc.description.pages259S-265Sen
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/10795930en
dc.type.austinJournal Articleen
local.name.researcherBurrell, Louise M
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
item.openairetypeJournal Article-
item.grantfulltextnone-
item.cerifentitytypePublications-
crisitem.author.deptCardiology-
crisitem.author.deptGeneral Medicine-
crisitem.author.deptMedicine (University of Melbourne)-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

30
checked on May 26, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.