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dc.contributor.authorBurrell, Louise Men
dc.contributor.authorRisvanis, Johnen
dc.contributor.authorJohnston, Colin Ien
dc.contributor.authorNaitoh, Men
dc.contributor.authorBalding, Leanne Cen
dc.identifier.citationExperimental Physiology; 85 Spec No(): 259S-265Sen
dc.description.abstractThe precise role of vasopressin in the pathophysiology of cardiovascular disease is controversial, but this peptide hormone is important for several reasons. Firstly, circulating concentrations of vasopressin are elevated in heart failure and some forms of hypertension. Secondly, there is evidence that vasopressin is synthesized not only in the hypophysial-pituitary axis but also in peripheral tissues including the heart where it acts as a paracrine hormone. Thirdly, vasopressin has vasoconstrictor, mitogenic, hyperplastic and renal fluid retaining properties which, by analogy with angiotensin II, may have deleterious effects when present in chronic excess. Finally, the availability of orally active non-peptide vasopressin receptor antagonists allows vasopressin receptor antagonism to be considered as a therapeutic option in cardiovascular disease.en
dc.subject.otherAntidiuretic Hormone Receptor Antagonistsen
dc.subject.otherBenzazepines.therapeutic useen
dc.subject.otherHeart Failure.drug therapy.physiopathologyen
dc.subject.otherHypertension.drug therapy.physiopathologyen
dc.subject.otherMorpholines.therapeutic useen
dc.subject.otherReceptors, Vasopressin.physiologyen
dc.subject.otherSpiro Compounds.therapeutic useen
dc.titleVasopressin receptor antagonism--a therapeutic option in heart failure and hypertension.en
dc.typeJournal Articleen
dc.identifier.journaltitleExperimental physiologyen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australiaen
dc.type.austinJournal Articleen, Louise M
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.cerifentitytypePublications- Medicine- (University of Melbourne)-
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