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Title: Multiple physiological functions for multidrug transporter P-glycoprotein?
Austin Authors: Johnstone, R W;Ruefli, A A;Smyth, Mark J
Affiliation: Cellular Cytotoxicity Laboratory, The Austin Research Institute, Austin Hospital, Studley Road, Heidelberg 3084, Victoria, Australia
Issue Date: 1-Jan-2000
Publication information: Trends in Biochemical Sciences; 25(1): 1-6
Abstract: Multidrug resistance mediated by the drug-efflux protein P-glycoprotein (P-gp) is one mechanism that tumor cells use to escape death induced by chemotherapeutic drugs. Although it is irrefutable that P-gp can efflux xenobiotics out of cells, biological regulatory functions for P-gp in multicellular organisms have yet to be established firmly. Recent observations have challenged the notion that P-gp has evolved merely to efflux xenotoxins out of healthy cells and raised the possibility that P-gp and related transporter molecules might play a fundamental role in regulating cell differentiation, proliferation and survival.
Gov't Doc #: 10637601
Journal: Trends in biochemical sciences
Type: Journal Article
Subjects: Animals
Biological Transport
Cell Death.physiology
Cell Differentiation.physiology
Drug Resistance, Multiple.physiology
Lipid Metabolism
Appears in Collections:Journal articles

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