Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9201
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dc.contributor.authorJohnstone, R Wen
dc.contributor.authorRuefli, A Aen
dc.contributor.authorSmyth, Mark Jen
dc.date.accessioned2015-05-15T22:12:20Z
dc.date.available2015-05-15T22:12:20Z
dc.date.issued2000-01-01en
dc.identifier.citationTrends in Biochemical Sciences; 25(1): 1-6en
dc.identifier.govdoc10637601en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/9201en
dc.description.abstractMultidrug resistance mediated by the drug-efflux protein P-glycoprotein (P-gp) is one mechanism that tumor cells use to escape death induced by chemotherapeutic drugs. Although it is irrefutable that P-gp can efflux xenobiotics out of cells, biological regulatory functions for P-gp in multicellular organisms have yet to be established firmly. Recent observations have challenged the notion that P-gp has evolved merely to efflux xenotoxins out of healthy cells and raised the possibility that P-gp and related transporter molecules might play a fundamental role in regulating cell differentiation, proliferation and survival.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherBiological Transporten
dc.subject.otherCell Death.physiologyen
dc.subject.otherCell Differentiation.physiologyen
dc.subject.otherCholesterol.metabolismen
dc.subject.otherDrug Resistance, Multiple.physiologyen
dc.subject.otherHumansen
dc.subject.otherLipid Metabolismen
dc.subject.otherP-Glycoprotein.physiologyen
dc.titleMultiple physiological functions for multidrug transporter P-glycoprotein?en
dc.typeJournal Articleen
dc.identifier.journaltitleTrends in biochemical sciencesen
dc.identifier.affiliationCellular Cytotoxicity Laboratory, The Austin Research Institute, Austin Hospital, Studley Road, Heidelberg 3084, Victoria, Australiaen
dc.description.pages1-6en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/10637601en
dc.type.austinJournal Articleen
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
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