Austin Health

Title
Multiple physiological functions for multidrug transporter P-glycoprotein?
Publication Date
2000-01-01
Author(s)
Johnstone, R W
Ruefli, A A
Smyth, Mark J
Type of document
Journal Article
Abstract
Multidrug resistance mediated by the drug-efflux protein P-glycoprotein (P-gp) is one mechanism that tumor cells use to escape death induced by chemotherapeutic drugs. Although it is irrefutable that P-gp can efflux xenobiotics out of cells, biological regulatory functions for P-gp in multicellular organisms have yet to be established firmly. Recent observations have challenged the notion that P-gp has evolved merely to efflux xenotoxins out of healthy cells and raised the possibility that P-gp and related transporter molecules might play a fundamental role in regulating cell differentiation, proliferation and survival.
Link
Citation
Trends in Biochemical Sciences; 25(1): 1-6
Jornal Title
Trends in biochemical sciences

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