Please use this identifier to cite or link to this item:
|Title:||Multiple physiological functions for multidrug transporter P-glycoprotein?||Austin Authors:||Johnstone, R W;Ruefli, A A;Smyth, Mark J||Affiliation:||Cellular Cytotoxicity Laboratory, The Austin Research Institute, Austin Hospital, Studley Road, Heidelberg 3084, Victoria, Australia||Issue Date:||1-Jan-2000||Publication information:||Trends in Biochemical Sciences; 25(1): 1-6||Abstract:||Multidrug resistance mediated by the drug-efflux protein P-glycoprotein (P-gp) is one mechanism that tumor cells use to escape death induced by chemotherapeutic drugs. Although it is irrefutable that P-gp can efflux xenobiotics out of cells, biological regulatory functions for P-gp in multicellular organisms have yet to be established firmly. Recent observations have challenged the notion that P-gp has evolved merely to efflux xenotoxins out of healthy cells and raised the possibility that P-gp and related transporter molecules might play a fundamental role in regulating cell differentiation, proliferation and survival.||Gov't Doc #:||10637601||URI:||http://ahro.austin.org.au/austinjspui/handle/1/9201||URL:||https://pubmed.ncbi.nlm.nih.gov/10637601||Type:||Journal Article||Subjects:||Animals
Drug Resistance, Multiple.physiology
|Appears in Collections:||Journal articles|
Show full item record
checked on Nov 29, 2022
Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.