Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9192
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dc.contributor.authorJackson, Graeme Den
dc.contributor.authorKim, S Een
dc.contributor.authorFitt, Gregory Jen
dc.contributor.authorMitchell, A Len
dc.contributor.authorSyngeniotis, Arien
dc.contributor.authorBerkovic, Samuel Fen
dc.date.accessioned2015-05-15T22:11:24Z
dc.date.available2015-05-15T22:11:24Z
dc.date.issued1999-11-01en
dc.identifier.citationDevelopmental Neuroscience; 21(3-5): 200-6en
dc.identifier.govdoc10575243en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/9192en
dc.description.abstractWe performed hippocampal T(2) relaxometry as part of a routine magnetic resonance imaging (MRI) examination in 50 normal controls and 127 consecutive patients referred because of suspected seizures.On the basis of T(2) values in controls (100.2 +/- 4.2 ms) we defined normal as <110 ms (<mean + 2 SD), borderline as 110-113 ms (mean + 2 SD to mean + 3 SD) and abnormal as >113 ms (>mean + 3 SD).After detailed investigation, 103 of these 127 patients had epilepsy and 24 did not. In the nonepilepsy group, none had abnormal hippocampal T(2) values. Twenty-seven of the 103 patients in the epilepsy group had abnormal values, 7 were borderline and 69 were normal. Only 5 patients with abnormal T(2) values did not have temporal lobe epilepsy: 1 had extratemporal lobe epilepsy, 1 had generalized epilepsy and 3 had unclassified epilepsy. Twenty-two of 27 (81%) patients with abnormal hippocampal T(2) values had intractable epilepsy [compared with 32 of 69 (46%) patients with normal values; p < 0.05, chi(2) test]. Two thirds of patients with abnormal values had a history of a major antecedent event (compared to only 7% of those with normal values, p < 0.05, chi(2) test).Abnormal T(2) relaxometry is significantly associated with intractable epilepsy as well as with major antecedent events.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAge of Onseten
dc.subject.otherEpilepsy.diagnosisen
dc.subject.otherEpilepsy, Temporal Lobe.diagnosisen
dc.subject.otherFemaleen
dc.subject.otherHippocampus.pathologyen
dc.subject.otherHumansen
dc.subject.otherMagnetic Resonance Imagingen
dc.subject.otherMaleen
dc.subject.otherPrognosisen
dc.subject.otherSeizures.diagnosis.epidemiologyen
dc.titleHippocampal T(2) abnormalities correlate with antecedent events and help predict seizure intractability.en
dc.typeJournal Articleen
dc.identifier.journaltitleDevelopmental neuroscienceen
dc.identifier.affiliationBrain Imaging Research Institute, Departments of Neurology and Radiology, Boronia Centre, West Heidelberg, Austin and Repatriation Medical Centre, Howard Florey Institute and Department of Medicine University of Melbourne, Victoria, Australiaen
dc.identifier.doi17399en
dc.description.pages200-6en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/10575243en
dc.type.austinJournal Articleen
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
crisitem.author.deptNeurology-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptRadiology-
crisitem.author.deptEpilepsy Research Centre-
crisitem.author.deptNeurology-
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