Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9176
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dc.contributor.authorDodd, Seetalen
dc.contributor.authorBuist, Anneen
dc.contributor.authorBurrows, Graham Den
dc.contributor.authorMaguire, K Pen
dc.contributor.authorNorman, Trevor Ren
dc.date.accessioned2015-05-15T22:10:01Z
dc.date.available2015-05-15T22:10:01Z
dc.date.issued1999-07-09en
dc.identifier.citationJournal of Chromatography. B, Biomedical Sciences and Applications; 730(2): 249-55en
dc.identifier.govdoc10448960en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/9176en
dc.description.abstractA method is described for the determination of nefazodone and its active metabolites hydroxynefazodone, the dione BMS-180492 and m-chlorophenylpiperazine in blood plasma and expressed human milk based on reversed-phase high-performance liquid chromatography. Measurements were performed on drug-free plasma and expressed human milk spiked with nefazodone and metabolites to prepare and validate standard curves and specimens collected from nursing mothers. Parent drug and metabolites were separated from the biological matrices by solid-phase extraction using CERTIFY columns. Chromatographic separation was achieved with a C18 column and compounds were detected by their absorbance at 205 nm. Trazodone was used as an internal standard. The assay was validated for each analyte in the concentration range 200 to 1200 ng/ml.en
dc.language.isoenen
dc.subject.otherAntidepressive Agents, Second-Generation.analysis.blooden
dc.subject.otherChromatography, High Pressure Liquid.methodsen
dc.subject.otherHumansen
dc.subject.otherMilk, Human.chemistryen
dc.subject.otherReference Standardsen
dc.subject.otherReproducibility of Resultsen
dc.subject.otherTriazoles.analysis.blooden
dc.titleDetermination of nefazodone and its pharmacologically active metabolites in human blood plasma and breast milk by high-performance liquid chromatography.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of chromatography. B, Biomedical sciences and applicationsen
dc.identifier.affiliationDepartment of Psychiatry, University of Melbourne, Austin and Repatriation Medical Centre, Victoria, Australiaen
dc.description.pages249-55en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/10448960en
dc.type.austinJournal Articleen
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
crisitem.author.deptPsychiatry (University of Melbourne)-
crisitem.author.deptPsychiatry (University of Melbourne)-
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