Please use this identifier to cite or link to this item:
https://ahro.austin.org.au/austinjspui/handle/1/34996
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Meersch, Melanie | - |
dc.contributor.author | Weiss, Raphael | - |
dc.contributor.author | Strauß, Christian | - |
dc.contributor.author | Albert, Felix | - |
dc.contributor.author | Booke, Hendrik | - |
dc.contributor.author | Forni, Lui | - |
dc.contributor.author | Pittet, Jean-Francois | - |
dc.contributor.author | Kellum, John A | - |
dc.contributor.author | Rosner, Mitchell | - |
dc.contributor.author | Mehta, Ravindra | - |
dc.contributor.author | Bellomo, Rinaldo | - |
dc.contributor.author | Rosenberger, Peter | - |
dc.contributor.author | Zarbock, Alexander | - |
dc.date | 2024 | - |
dc.date.accessioned | 2024-01-30T23:47:17Z | - |
dc.date.available | 2024-01-30T23:47:17Z | - |
dc.date.issued | 2024-01-29 | - |
dc.identifier.citation | Intensive Care Medicine 2024-01-29 | en_US |
dc.identifier.issn | 1432-1238 | - |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/34996 | - |
dc.description.abstract | Acute kidney disease (AKD) is a significant health care burden worldwide. However, little is known about this complication after major surgery. We conducted an international prospective, observational, multi-center study among patients undergoing major surgery. The primary study endpoint was the incidence of AKD (defined as new onset of estimated glomerular filtration rate (eCFR) < 60 ml/min/1.73 m2 present on day 7 or later) among survivors. Secondary endpoints included the relationship between early postoperative acute kidney injury (AKI) (within 72 h after major surgery) and subsequent AKD, the identification of risk factors for AKD, and the rate of chronic kidney disease (CKD) progression in patients with pre-existing CKD. We studied 9510 patients without pre-existing CKD. Of these, 940 (9.9%) developed AKD after 7 days of whom 34.1% experiencing an episode of early postoperative-AKI. Rates of AKD after 7 days significantly increased with the severity (19.1% Kidney Disease Improving Global Outcomes [KDIGO] 1, 24.5% KDIGO2, 34.3% KDIGO3; P < 0.001) and duration (15.5% transient vs 38.3% persistent AKI; P < 0.001) of early postoperative-AKI. Independent risk factors for AKD included early postoperative-AKI, exposure to perioperative nephrotoxic agents, and postoperative pneumonia. Early postoperative-AKI carried an independent odds ratio for AKD of 2.64 (95% confidence interval [CI] 2.21-3.15). Of 663 patients with pre-existing CKD, 42 (6.3%) had worsening CKD at day 90. In patients with CKD and an episode of early AKI, CKD progression occurred in 11.6%. One in ten major surgery patients developed AKD beyond 7 days after surgery, in most cases without an episode of early postoperative-AKI. However, early postoperative-AKI severity and duration were associated with an increased rate of AKD and early postoperative-AKI was strongly associated with AKD independent of all other potential risk factors. | en_US |
dc.language.iso | eng | - |
dc.subject | Acute kidney disease | en_US |
dc.subject | Acute kidney injury | en_US |
dc.subject | Chronic kidney disease | en_US |
dc.subject | Postoperative | en_US |
dc.subject | Surgery | en_US |
dc.title | Acute kidney disease beyond day 7 after major surgery: a secondary analysis of the EPIS-AKI trial. | en_US |
dc.type | Journal Article | en_US |
dc.identifier.journaltitle | Intensive Care Medicine | en_US |
dc.identifier.affiliation | Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Albert-Schweitzer-Campus 1, Gebäude A1, 48149, Münster, Germany. | en_US |
dc.identifier.affiliation | Institute of Biostatistics and Clinical Research, University of Münster, Münster, Germany. | en_US |
dc.identifier.affiliation | Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Albert-Schweitzer-Campus 1, Gebäude A1, 48149, Münster, Germany. | en_US |
dc.identifier.affiliation | School of Medicine, University of Surrey, Kate Granger Building, Guildford, UK.;Intensive Care Unit, Royal Surrey Hospital, Guildford, UK. | en_US |
dc.identifier.affiliation | Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, USA. | en_US |
dc.identifier.affiliation | Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA. | en_US |
dc.identifier.affiliation | Department of Medicine, University of Virginia, Charlottesville, VA, USA. | en_US |
dc.identifier.affiliation | Department of Medicine, University of California San Diego, San Diego, CA, USA. | en_US |
dc.identifier.affiliation | Department of Critical Care, The University of Melbourne, Melbourne, Australia.;Department of Intensive Care, Royal Melbourne Hospital, Parkville, VIC, Australia.;Department of Intensive Care, Austin Health, Heidelberg, Australia.;Australian and New Zealand Intensive Care Research Centre, School orsity, Melbourne, Australia.f Public Health and Preventive Medicine, Monash Unive | en_US |
dc.identifier.affiliation | Department of Anesthesiology and Intensive Care, University Hospital Tübingen, Tübingen, Germany. | en_US |
dc.identifier.affiliation | Intensive Care | en_US |
dc.identifier.doi | 10.1007/s00134-023-07314-2 | en_US |
dc.type.content | Text | en_US |
dc.identifier.orcid | 0000-0002-2124-1714 | en_US |
dc.identifier.pubmedid | 38285051 | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.openairetype | Journal Article | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Intensive Care | - |
crisitem.author.dept | Data Analytics Research and Evaluation (DARE) Centre | - |
Appears in Collections: | Journal articles |
Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.