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https://ahro.austin.org.au/austinjspui/handle/1/33950| Title: | Longitudinal trajectories of basal forebrain volume in normal aging and Alzheimer's disease. | Austin Authors: | Xia, Ying;Maruff, Paul;Doré, Vincent ;Bourgeat, Pierrick;Laws, Simon M;Fowler, Christopher;Rainey-Smith, Stephanie R;Martins, Ralph N;Villemagne, Victor L ;Rowe, Christopher C ;Masters, Colin L ;Coulson, Elizabeth J;Fripp, Jurgen | Affiliation: | The Australian e-Health Research Centre, CSIRO Health and Biosecurity, Brisbane, Queensland, Australia. Cogstate Ltd, Melbourne, Victoria, Australia; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia. Nuclear Medicine and Centre for PET, Austin Health, Melbourne, Victoria, Australia; The Australian e-Health Research Centre, CSIRO Health and Biosecurity, Melbourne, Victoria, Australia. The Australian e-Health Research Centre, CSIRO Health and Biosecurity, Brisbane, Queensland, Australia. Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia; Centre for Precision Health, Edith Cowan University, Joondalup, Western Australia, Australia; Curtin Medical School, Curtin University, Bentley, Western Australia, Australia. The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia. Centre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, Western Australia, Australia; Australian Alzheimer's Research Foundation, Sarich Neuroscience Research Institute, Nedlands, Western Australia, Australia; School of Psychological Science, University of Western Australia, Crawley, Western Australia, Australia; School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia. Australian Alzheimer's Research Foundation, Sarich Neuroscience Research Institute, Nedlands, Western Australia, Australia; School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia; Department of Biomedical Sciences, Macquarie University, Sydney, New South Wales, Australia. Austin Health Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia; School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland, Australia. |
Issue Date: | 11-Sep-2023 | Date: | 2023 | Publication information: | Neurobiology of Aging 2023-09-11; 132 | Abstract: | Dysfunction of the cholinergic basal forebrain (BF) system and amyloid-β (Aβ) deposition are early pathological features in Alzheimer's disease (AD). However, their association in early AD is not well-established. This study investigated the nature and magnitude of volume loss in the BF, over an extended period, in 516 older adults who completed Aβ-PET and serial magnetic resonance imaging scans. Individuals were grouped at baseline according to the presence of cognitive impairment (CU, CI) and Aβ status (Aβ-, Aβ+). Longitudinal volumetric changes in the BF and hippocampus were assessed across groups. The results indicated that high Aβ levels correlated with faster volume loss in the BF and hippocampus, and the effect of Aβ varied within BF subregions. Compared to CU Aβ+ individuals, Aβ-related loss among CI Aβ+ adults was much greater in the predominantly cholinergic subregion of Ch4p, whereas no difference was observed for the Ch1/Ch2 region. The findings support early and substantial vulnerability of the BF and further reveal distinctive degeneration of BF subregions during early AD. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/33950 | DOI: | 10.1016/j.neurobiolaging.2023.09.002 | ORCID: | Journal: | Neurobiology of Aging | Start page: | 120 | End page: | 130 | PubMed URL: | 37801885 | ISSN: | 1558-1497 | Type: | Journal Article | Subjects: | Alzheimer’s disease Amyloid-β Basal forebrain Longitudinal Magnetic resonance imaging |
| Appears in Collections: | Journal articles |
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