Austin Health

Title
Longitudinal trajectories of basal forebrain volume in normal aging and Alzheimer's disease.
Publication Date
2023-09-11
Author(s)
Xia, Ying
Maruff, Paul
Doré, Vincent
Bourgeat, Pierrick
Laws, Simon M
Fowler, Christopher
Rainey-Smith, Stephanie R
Martins, Ralph N
Villemagne, Victor L
Rowe, Christopher C
Masters, Colin L
Coulson, Elizabeth J
Fripp, Jurgen
Subject
Alzheimer’s disease
Amyloid-β
Basal forebrain
Longitudinal
Magnetic resonance imaging
Type of document
Journal Article
OrcId
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
DOI
10.1016/j.neurobiolaging.2023.09.002
Abstract
Dysfunction of the cholinergic basal forebrain (BF) system and amyloid-β (Aβ) deposition are early pathological features in Alzheimer's disease (AD). However, their association in early AD is not well-established. This study investigated the nature and magnitude of volume loss in the BF, over an extended period, in 516 older adults who completed Aβ-PET and serial magnetic resonance imaging scans. Individuals were grouped at baseline according to the presence of cognitive impairment (CU, CI) and Aβ status (Aβ-, Aβ+). Longitudinal volumetric changes in the BF and hippocampus were assessed across groups. The results indicated that high Aβ levels correlated with faster volume loss in the BF and hippocampus, and the effect of Aβ varied within BF subregions. Compared to CU Aβ+ individuals, Aβ-related loss among CI Aβ+ adults was much greater in the predominantly cholinergic subregion of Ch4p, whereas no difference was observed for the Ch1/Ch2 region. The findings support early and substantial vulnerability of the BF and further reveal distinctive degeneration of BF subregions during early AD.
Link
Citation
Neurobiology of Aging 2023-09-11; 132
Jornal Title
Neurobiology of Aging
ISSN
1558-1497

Files:

NameSizeformatDescriptionLink