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dc.contributor.authorTakagi, Michael-
dc.contributor.authorBall, Gareth-
dc.contributor.authorBabl, Franz E-
dc.contributor.authorAnderson, Nicholas-
dc.contributor.authorChen, Jian-
dc.contributor.authorClarke, Cathriona-
dc.contributor.authorDavis, Gavin A-
dc.contributor.authorHearps, Stephen J C-
dc.contributor.authorPascouau, Renee-
dc.contributor.authorCheng, Nicholas-
dc.contributor.authorRausa, Vanessa C-
dc.contributor.authorSeal, Marc-
dc.contributor.authorShapiro, Jesse S-
dc.contributor.authorAnderson, Vicki-
dc.identifier.citationNeuroImage. Clinical 2023-08-08; 39en_US
dc.description.abstractDiffusion-Weight Imaging (DWI) is increasingly used to explore a range of outcomes in pediatric concussion, particularly the neurobiological underpinnings of symptom recovery. However, the DWI findings within the broader pediatric concussion literature are mixed, which can largely be explained by methodological heterogeneity. To address some of these limitations, the aim of the present study was to utilize internationally- recognized criteria for concussion and a consistent imaging timepoint to conduct a comprehensive, multi-parametric survey of white matter microstructure after concussion. Forty-three children presenting with concussion to the emergency department of a tertiary level pediatric hospital underwent neuroimaging and were classified as either normally recovering (n = 27), or delayed recovering (n = 14) based on their post-concussion symptoms at 2 weeks post-injury.We combined multiple DWI metrics across four modeling approaches using Linked Independent Component Analysis (LICA) to extract several independent patterns of covariation in tissue microstructure present in the study cohort. Our analysis did not identify significant differences between the symptomatic and asymptomatic groups and no component significantly predicted delayed recovery. If white matter microstructure changes are implicated in delayed recovery from concussion, these findings, alongside previous work, suggest that current diffusion techniques are insufficient to detect those changes at this time.en_US
dc.subjectDiffusion weighted imagingen_US
dc.subjectMild traumatic brain injuryen_US
dc.subjectPediatric concussionen_US
dc.subjectPediatric neuroimagingen_US
dc.subjectPersisting post-concussion symptomsen_US
dc.subjectPost-concussion syndromeen_US
dc.titleExamining post-concussion white matter change in a pediatric sample.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleNeuroImage. Clinicalen_US
dc.identifier.affiliationMurdoch Children's Research Institute, Melbourne, Victoria, Australia.en_US
dc.identifier.affiliationDepartment of Paediatrics, University of Melbourne, Victoria, Australia.en_US
dc.identifier.affiliationMelbourne School of Psychological Sciences, University of Melbourne, Victoria, Australia.en_US
dc.identifier.affiliationDepartment of Rehabilitation Medicine, The Royal Children's Hospital, Melbourne, Victoria, Australia; Monash School of Psychological Sciences, Monash University, Clayton, Victoria, Australia.en_US
dc.identifier.affiliationDepartment of Neurosurgery,Cabrini Hospitals, Melbourne, Victoria, Australia.en_US
item.fulltextNo Fulltext-
item.openairetypeJournal Article- Florey Institute of Neuroscience and Mental Health-
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