Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/33276
Title: CenTauR: Toward a universal scale and masks for standardizing tau imaging studies.
Austin Authors: Villemagne, Victor L ;Leuzy, Antoine;Bohorquez, Sandra Sanabria;Bullich, Santiago;Shimada, Hitoshi;Rowe, Christopher C ;Bourgeat, Pierrick;Lopresti, Brian;Huang, Kun ;Krishnadas, Natasha ;Fripp, Jurgen;Takado, Yuhei;Gogola, Alexandra;Minhas, Davneet;Weimer, Robby;Higuchi, Makoto;Stephens, Andrew;Hansson, Oskar;Doré, Vincent 
Affiliation: Department of Psychiatry University of Pittsburgh Pittsburgh Pennsylvania USA.
Clinical Memory Research Unit Department of Clinical Sciences Lund University Malmö Sweden.
Genentech Inc. South San Francisco California USA.
Life Molecular Imaging GmbH Berlin Germany.
Department of Functional Brain Imaging National Institutes for Quantum and Radiological Science and Technology Chiba Japan.;Brain Research Institute Niigata University Niigata Japan.
Department of Molecular Imaging & Therapy Austin Health Melbourne Victoria Australia.;Florey Department of Neurosciences & Mental Health The University of Melbourne Melbourne Parkville Australia.;The Australian Dementia Network (ADNeT) Melbourne Victoria Australia.
Health and Biosecurity Flagship The Australian eHealth Research Centre CSIRO Brisbane Queensland Australia.
Department of Radiology University of Pittsburgh Pittsburgh Pennsylvania USA.
Molecular Imaging and Therapy
The Florey Institute of Neuroscience and Mental Health
Health and Biosecurity Flagship The Australian eHealth Research Centre CSIRO Brisbane Queensland Australia.
Department of Functional Brain Imaging National Institutes for Quantum and Radiological Science and Technology Chiba Japan.
Department of Radiology University of Pittsburgh Pittsburgh Pennsylvania USA.
Genentech Inc. South San Francisco California USA.
Department of Functional Brain Imaging National Institutes for Quantum and Radiological Science and Technology Chiba Japan.
Life Molecular Imaging GmbH Berlin Germany.
Clinical Memory Research Unit Department of Clinical Sciences Lund University Malmö Sweden.;Memory Clinic Skåne University Hospital Malmö Sweden.
Health and Biosecurity Flagship The Australian eHealth Research Centre CSIRO Heidelberg Victoria Australia.
Issue Date: 2023
Date: 2023
Publication information: Alzheimer's & Dementia (Amsterdam, Netherlands) 2023; 15(3)
Abstract: Recently, an increasing number of tau tracers have become available. There is a need to standardize quantitative tau measures across tracers, supporting a universal scale. We developed several cortical tau masks and applied them to generate a tau imaging universal scale. One thousand forty-five participants underwent tau scans with either 18F-flortaucipir, 18F-MK6240, 18F-PI2620, 18F-PM-PBB3, 18F-GTP1, or 18F-RO948. The universal mask was generated from cognitively unimpaired amyloid beta (Aβ)- subjects and Alzheimer's disease (AD) patients with Aβ+. Four additional regional cortical masks were defined within the constraints of the universal mask. A universal scale, the CenTauRz, was constructed. None of the regions known to display off-target signal were included in the masks. The CenTauRz allows robust discrimination between low and high levels of tau deposits. We constructed several tau-specific cortical masks for the AD continuum and a universal standard scale designed to capture the location and degree of abnormality that can be applied across tracers and across centers. The masks are freely available at https://www.gaain.org/centaur-project.
URI: https://ahro.austin.org.au/austinjspui/handle/1/33276
DOI: 10.1002/dad2.12454
ORCID: 
Journal: Alzheimer's & Dementia (Amsterdam, Netherlands)
Start page: e12454
PubMed URL: 37424964
Type: Journal Article
Appears in Collections:Journal articles

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