Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/32964
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dc.contributor.authorJones, Jennifer R A-
dc.contributor.authorKarahalios, Amalia-
dc.contributor.authorPuthucheary, Zudin A-
dc.contributor.authorBerry, Michael J-
dc.contributor.authorFiles, D Clark-
dc.contributor.authorGriffith, David M-
dc.contributor.authorMcDonald, Luke A-
dc.contributor.authorMorris, Peter E-
dc.contributor.authorMoss, Marc-
dc.contributor.authorNordon-Craft, Amy-
dc.contributor.authorWalsh, Timothy-
dc.contributor.authorBerney, Sue-
dc.contributor.authorDenehy, Linda-
dc.date2023-
dc.date.accessioned2023-06-07T02:37:12Z-
dc.date.available2023-06-07T02:37:12Z-
dc.date.issued2023-10-01-
dc.identifier.citationCritical Care Medicine 2023-10-01; 51(10)en_US
dc.identifier.issn1530-0293-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/32964-
dc.description.abstractTo explore if patient characteristics (pre-existing comorbidity, age, sex, and illness severity) modify the effect of physical rehabilitation (intervention vs control) for the coprimary outcomes health-related quality of life (HRQoL) and objective physical performance using pooled individual patient data from randomized controlled trials (RCTs). Data of individual patients from four critical care physical rehabilitation RCTs. Eligible trials were identified from a published systematic review. Data sharing agreements were executed permitting transfer of anonymized data of individual patients from four trials to form one large, combined dataset. The pooled trial data were analyzed with linear mixed models fitted with fixed effects for treatment group, time, and trial. Four trials contributed data resulting in a combined total of 810 patients (intervention n = 403, control n = 407). After receiving trial rehabilitation interventions, patients with two or more comorbidities had HRQoL scores that were significantly higher and exceeded the minimal important difference at 3 and 6 months compared with the similarly comorbid control group (based on the Physical Component Summary score (Wald test p = 0.041). Patients with one or no comorbidities who received intervention had no HRQoL outcome differences at 3 and 6 months when compared with similarly comorbid control patients. No patient characteristic modified the physical performance outcome in patients who received physical rehabilitation. The identification of a target group with two or more comorbidities who derived benefits from the trial interventions is an important finding and provides direction for future investigations into the effect of rehabilitation. The multimorbid post-ICU population may be a select population for future prospective investigations into the effect of physical rehabilitation.en_US
dc.language.isoeng-
dc.titleResponsiveness of Critically Ill Adults With Multimorbidity to Rehabilitation Interventions: A Patient-Level Meta-Analysis Using Individual Pooled Data From Four Randomized Trials.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleCritical Care Medicineen_US
dc.identifier.affiliationPhysiotherapy Department, The University of Melbourne, Parkville, Victoria, Australia.en_US
dc.identifier.affiliationCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.en_US
dc.identifier.affiliationWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, England, United Kingdom.;Adult Critical Care Unit, Royal London Hospital, Barts Health NHS Trust, London, England, United Kingdom.en_US
dc.identifier.affiliationDepartment of Health and Exercise Science, Wake Forest University, Winston Salem, NC.en_US
dc.identifier.affiliationPulmonary, Critical Care, Allergy and Immunologic Disease, Wake Forest University, Winston-Salem, NC.;Wake Forest Critical Illness Injury and Recovery Research Center, Wake Forest University, Winston Salem, NC.en_US
dc.identifier.affiliationDeanery of Molecular, Genetic and Population Health Sciences, The University of Edinburgh, Edinburgh, United Kingdom.;Royal Infirmary of Edinburgh, NHS (National Health Service) Lothian, Edinburgh, Scotland, United Kingdom.en_US
dc.identifier.affiliationPhysiotherapy Department, Division of Allied Health, Austin Health, Heidelberg, Victoria, Australia.en_US
dc.identifier.affiliationDivision of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL.en_US
dc.identifier.affiliationDivision of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Aurora, CO.en_US
dc.identifier.affiliationPhysical Therapy Program, University of Colorado School of Medicine, Aurora, CO.en_US
dc.identifier.affiliationDeanery of Molecular, Genetic and Population Health Sciences, The University of Edinburgh, Edinburgh, United Kingdom.;Anaesthetics, Critical Care, and Pain Medicine, School of Clinical Sciences, Queens Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, United Kingdom.;Centre for Population Health Sciences, Usher Institute, University of Edinburgh, Edinburgh, Scotland, United Kingdom.en_US
dc.identifier.affiliationPhysiotherapyen_US
dc.identifier.affiliationMelbourne School of Health Sciences, The University of Melbourne, Parkville, Victoria, Australia.;Allied Health, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.en_US
dc.identifier.affiliationInstitute for Breathing and Sleepen_US
dc.identifier.doi10.1097/CCM.0000000000005936en_US
dc.type.contentTexten_US
dc.identifier.pubmedid37246922-
local.name.researcherBerney, Susan C-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
crisitem.author.deptPhysiotherapy-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
crisitem.author.deptPhysiotherapy-
crisitem.author.deptPhysiotherapy-
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