Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/32360
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dc.contributor.authorHinton, Jake V-
dc.contributor.authorXing, Zhongyue-
dc.contributor.authorFletcher, Calvin M-
dc.contributor.authorPerry, Luke A-
dc.contributor.authorKaramesinis, Alexandra-
dc.contributor.authorShi, Jenny-
dc.contributor.authorRamson, Dhruvesh M-
dc.contributor.authorPenny-Dimri, Jahan C-
dc.contributor.authorLiu, Zhengyang-
dc.contributor.authorWilliams-Spence, Jenni-
dc.contributor.authorCoulson, Tim G-
dc.contributor.authorSmith, Julian A-
dc.contributor.authorSegal, Reny-
dc.contributor.authorBellomo, Rinaldo-
dc.date2023-
dc.date.accessioned2023-03-22T02:18:52Z-
dc.date.available2023-03-22T02:18:52Z-
dc.date.issued2023-08-
dc.identifier.citationThe Annals of Thoracic Surgery 2023-08; 116(2)en_US
dc.identifier.issn1552-6259-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/32360-
dc.description.abstractCryoprecipitate is often transfused in patients undergoing cardiac surgery. However, its safety and effectiveness remains uncertain. We conducted a propensity-score matched analysis of data from the Australian and New Zealand Society of Cardiac and Thoracic Surgeons National Cardiac Surgery Database. We included adults undergoing cardiac surgery between 2005-2018 across 38 sites. We estimated the association between perioperative cryoprecipitate transfusion and clinical outcomes, with a primary outcome of operative mortality. Of 119,132 eligible patients, 11,239 (9.43%) patients received cryoprecipitate. The median cumulative dose was 8 units (interquartile range, 5 to 10). After propensity-score matching, we matched 9,055 cryoprecipitate recipients to 9,055 controls. Postoperative cryoprecipitate transfusion was associated with reduced operative (Odds Ratio [OR], 0.82; 99% confidence interval [CI], 0.69 to 0.97; P=0.002) and long term (Hazard Ratio, 0.92; 99% CI, 0.87 to 0.97; P=0.0042) mortality. It was also associated with a reduction in acute kidney injury (OR, 0.85; 99% CI, 0.73 to 0.98; P=0.0037] and all-cause infection (OR, 0.77; 99% CI, 0.67 to 0.88; P<0.0001). These findings were observed despite increased rates of return to operating theatre (OR, 1.36; 99% CI, 1.22 to 1.51; P<0.0001) and cumulative 4-hour postoperative chest tube output (Adjusted Mean Difference in mL, 97.69; 99% CI, 81.65 to 113.74; P<0.0001). In a large, multicentre cohort study and after propensity-score matching, perioperative transfusion of cryoprecipitate was associated with reduced operative and long-term mortality.en_US
dc.language.isoeng-
dc.titleAssociation of perioperative cryoprecipitate transfusion and mortality after cardiac surgery.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleThe Annals of Thoracic Surgeryen_US
dc.identifier.affiliationDepartment of Anaesthesia and Pain Management, Royal Melbourne Hospital, Parkville, Australia.en_US
dc.identifier.affiliationDepartment of Anaesthesiology and Perioperative Medicine, The Alfred Hospital and Monash University, Melbourne, Australia.en_US
dc.identifier.affiliationDepartment of Surgery, School of Clinical Sciences at Monash Health, Monash University, Clayton, Australia.en_US
dc.identifier.affiliationDepartment of Epidemiology and Preventive Medicine, Monash University, Clayton, Australia.en_US
dc.identifier.affiliationDepartment of Surgery, School of Clinical Sciences at Monash Health, Monash University, Clayton, Australia; Department of Cardiothoracic Surgery, Monash Health, Clayton, Australia.en_US
dc.identifier.affiliationDepartment of Critical Care, The University of Melbourne, Parkville, Australia.en_US
dc.identifier.affiliationAustralian and New Zealand Intensive Care Research Centre, Monash University, Clayton, Australia; Department of Intensive Care, Royal Melbourne Hospital, Melbourne, Australia.en_US
dc.identifier.affiliationIntensive Careen_US
dc.identifier.doi10.1016/j.athoracsur.2023.02.054en_US
dc.type.contentTexten_US
dc.identifier.pubmedid36914040-
local.name.researcherBellomo, Rinaldo-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptAnaesthesia-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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