Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/31111
Title: Characteristics of subjective cognitive decline associated with amyloid positivity.
Austin Authors: Janssen, Olin;Jansen, Willemijn J;Vos, Stephanie J B;Boada, Merce;Parnetti, Lucilla;Gabryelewicz, Tomasz;Fladby, Tormod;Molinuevo, José Luis;Villeneuve, Sylvia;Hort, Jakub;Epelbaum, Stéphane;Lleó, Alberto;Engelborghs, Sebastiaan;van der Flier, Wiesje M;Landau, Susan;Popp, Julius;Wallin, Anders;Scheltens, Philip;Rikkert, Marcel Olde;Snyder, Peter J;Rowe, Chris;Chételat, Gaël;Ruíz, Agustin;Marquié, Marta;Chipi, Elena;Wolfsgruber, Steffen;Heneka, Michael;Boecker, Henning;Peters, Oliver;Jarholm, Jonas;Rami, Lorena;Tort-Merino, Adrià;Binette, Alexa Pichet;Poirier, Judes;Rosa-Neto, Pedro;Cerman, Jiri;Dubois, Bruno;Teichmann, Marc;Alcolea, Daniel;Fortea, Juan;Sánchez-Saudinós, M Belén;Ebenau, Jarith;Pocnet, Cornelia;Eckerström, Marie;Thompson, Louisa;Villemagne, Victor L ;Buckley, Rachel;Burnham, Samantha;Delarue, Marion;Freund-Levi, Yvonne;Wallin, Åsa K;Ramakers, Inez;Tsolaki, Magda;Soininen, Hilkka;Hampel, Harald;Spiru, Luiza;Tijms, Betty;Ossenkoppele, Rik;Verhey, Frans R J;Jessen, Frank;Visser, Pieter Jelle
Affiliation: Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden..
Alzheimer Centre Limburg, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands..
Molecular Imaging and Therapy
Department of Psychiatry, University of Pittsburgh, Pittsburgh, USA..
CSIRO Health & Biosecurity, Parkville, Victoria, Australia
Alzheimer Centre Limburg, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands..
Fundació ACE, Institut Català de Neurociències Aplicades, Facultat de Medicina, Universitat International de Catalunya-Barcelona, Barcelona, Spain.. Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain..
Section of Neurology, Center for Memory Disturbances - Lab. of Clinical Neurochemistry, Department of Medicine and Surgery, University of Perugia, Perugia, Italy..
Department of Neurodegenerative Disorders, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland..
Department of Neurology, Akershus University Hospital, Lorenskog, Norway..
Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic of Barcelona, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain..
Centre for Studies on Prevention of Alzheimer's Disease (StOP-AD) Centre, Montreal, Quebec, Canada..
Department of Neurology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic.. International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic..
AP-HP, Hôpital de la Pitié Salpêtrière, Institute of Memory and Alzheimer's Disease (IM2A), Centre of excellence of neurodegenerative disease (CoEN), Department of Neurology, Paris, France.. Inserm Sorbonne Université, Inria, Aramis project-team, Paris Brain Institute - Institut du Cerveau (ICM), Paris, France..
Neurology Department, Hospital de Sant Pau, Barcelona, Spain.
Vrije Universiteit Brussel, (VUB) Brussels, and University of Antwerp, Antwerp, Belgium..
Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands..
Helen Wills Neuroscience Institute, University of California, Berkeley, California, USA..
Department of Geriatric Psychiatry, Psychiatric University Hospital, Zürich, Switzerland.. Old Age Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland..
Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands..
Department of Geriatric Medicine, Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, The Netherlands..
Institute of Clinical Medicine, University of Oslo, Oslo, Norway.. Kingston, The University of Rhode Island, Rhode Island, USA..
Institut National de la Sant. et de la Recherche M.dicale (Inserm), Caen, France..
Fundació ACE, Institut Català de Neurociències Aplicades, Facultat de Medicina, Universitat International de Catalunya-Barcelona, Barcelona, Spain.. Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain..
Section of Neurology, Center for Memory Disturbances - Lab. of Clinical Neurochemistry, Department of Medicine and Surgery, University of Perugia, Perugia, Italy..
German Center For Neurodegenerative Diseases/Clinical Research, Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE), Zentrum für klinische Forschung/AG, Cologne, Germany.. Department of Neurodegenerative Diseases and Psychiatry, University Hospital Bonn, Bonn, Germany..
Department of Neurodegenerative Diseases and Psychiatry, University Hospital Bonn, Bonn, Germany..
Functional Neuroimaging Group, Department of Radiology, University Hospital Bonn, Bonn, Germany..
Klinik für Psychiatrie und Psychotherapie, Charité Universitätsmedizin Berlin - CBF, Berlin, Deutschland..
Department of Neurology, Akershus University Hospital, Lorenskog, Norway..
Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic of Barcelona, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain..
Centre for Studies on Prevention of Alzheimer's Disease (StOP-AD) Centre, Montreal, Quebec, Canada..
Department of Neurology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic.. International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic..
AP-HP, Hôpital de la Pitié Salpêtrière, Institute of Memory and Alzheimer's Disease (IM2A), Centre of excellence of neurodegenerative disease (CoEN), Department of Neurology, Paris, France..
Neurology Department, Hospital de Sant Pau, Barcelona, Spain..
Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands..
Old Age Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland..
Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden..
Institute of Clinical Medicine, University of Oslo, Oslo, Norway.. Kingston, The University of Rhode Island, Rhode Island, USA..
Brigham and Women's Hospital and Department of Neurology Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA..
Section of Neurology, Center for Memory Disturbances - Lab. of Clinical Neurochemistry, Department of Medicine and Surgery, University of Perugia, Perugia, Italy..
Institut National de la Sant. et de la Recherche M.dicale (Inserm), Caen, France..
Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden..
Department of Clinical Sciences Malmö, Clinical Memory Research Unit, Lund University, Lund, Sweden..
Alzheimer Centre Limburg, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands..
Memory and Dementia Center, 3rd Department of Neurology, "G Papanicolau, " General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece..
Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland..
GRC no 21, Alzheimer Precision Medicine (AMP), AP-HP, Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France..
Carol DAVILA University of Medicine and Pharmacy, Bucharest, Romania.. Geriatrics- Gerontology and Old Age Psychiatry, Alzheimer Unit, Ana Aslan International Foundation - Memory Center and Longevity Medicine, Bucharest, Romania..
Alzheimer Centre Limburg, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands..
Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.. Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden.. Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic of Barcelona, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain..
Alzheimer Centre Limburg, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands..
Department of Psychiatry, University of Cologne, Cologne, Germany.. German Center For Neurodegenerative Diseases/Clinical Research, Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE), Zentrum für klinische Forschung/AG, Cologne, Germany.
Alzheimer Centre Limburg, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.. Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.. Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden..
Issue Date: Oct-2022
metadata.dc.date: 2021
Publication information: Alzheimer's & Dementia : the Journal of the Alzheimer's Association 2022; 18(10): 1832-1845
Abstract: The evidence for characteristics of persons with subjective cognitive decline (SCD) associated with amyloid positivity is limited. In 1640 persons with SCD from 20 Amyloid Biomarker Study cohort, we investigated the associations of SCD-specific characteristics (informant confirmation, domain-specific complaints, concerns, feelings of worse performance) demographics, setting, apolipoprotein E gene (APOE) ε4 carriership, and neuropsychiatric symptoms with amyloid positivity. Between cohorts, amyloid positivity in 70-year-olds varied from 10% to 76%. Only older age, clinical setting, and APOE ε4 carriership showed univariate associations with increased amyloid positivity. After adjusting for these, lower education was also associated with increased amyloid positivity. Only within a research setting, informant-confirmed complaints, memory complaints, attention/concentration complaints, and no depressive symptoms were associated with increased amyloid positivity. Feelings of worse performance were associated with less amyloid positivity at younger ages and more at older ages. Next to age, setting, and APOE ε4 carriership, SCD-specific characteristics may facilitate the identification of amyloid-positive individuals.
URI: https://ahro.austin.org.au/austinjspui/handle/1/31111
DOI: 10.1002/alz.12512
PubMed URL: 34877782
Type: Journal Article
Subjects: Alzheimer's disease
amyloid
cerebrospinal fluid
positron emission tomography
subjective cognitive decline
Appears in Collections:Journal articles

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