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dc.contributor.authorTan, Natassia-
dc.contributor.authorNgu, N-
dc.contributor.authorWorland, Thomas-
dc.contributor.authorLee, T-
dc.contributor.authorAbrahams, T-
dc.contributor.authorPandya, K-
dc.contributor.authorFreeman, E-
dc.contributor.authorHannah, N-
dc.contributor.authorGazelakis, K-
dc.contributor.authorMadden, R G-
dc.contributor.authorLynch, K D-
dc.contributor.authorValaydon, Z-
dc.contributor.authorSood, Siddharth-
dc.contributor.authorDev, A-
dc.contributor.authorBell, S-
dc.contributor.authorThompson, A-
dc.contributor.authorDing, J-
dc.contributor.authorNicoll, A J-
dc.contributor.authorLiu, K-
dc.contributor.authorGow, P-
dc.contributor.authorLubel, J-
dc.contributor.authorKemp, W-
dc.contributor.authorRoberts, S K-
dc.contributor.authorMajeed, A-
dc.identifier.citationHepatology International 2022; 16(5): 1094-1104en
dc.description.abstractLittle is known regarding the epidemiology and outcomes of patients with primary sclerosing cholangitis (PSC) in Australia. We, therefore, evaluated the epidemiology and clinical outcomes of PSC in a large cohort of Australian patients and compared these to the general population. We conducted a multicentre, retrospective cohort study of PSC patients at nine tertiary liver centers across three Australian states, including two liver transplant centers. A total of 413 PSC patients with 3,285 person-years of follow-up were included. Three hundred and seventy-one (90%) patients had large duct PSC and 294 (71%) had associated inflammatory bowel disease. A total of 168 (41%) patients developed cirrhosis (including 34 at the time of PSC diagnosis) after a median of 15.8 (95% CI 12.4, NA) years. The composite endpoint of death or liver transplantation occurred in 49 (12%) and 78 (19%) patients, respectively, with a median transplant-free survival of 13.4 (95% CI 12.2-15) years. Compared to the general population, PSC accounted for a 240-fold increased risk of development of cholangiocarcinoma (CCA) and CCA-related death. CCA risk was increased with older age of PSC diagnosis, presence of dominant stricture and colectomy. Compared to same-aged counterparts in the general population, PSC patients who were diagnosed at an older age or with longer disease duration had reduced relative survival. In this large retrospective cohort study of PSC patients in Australia, increased age and time from diagnosis was associated with increased mortality and morbidity particularly from CCA and development of cirrhosis, necessitating need for liver transplant.en
dc.subjectLiver transplanten
dc.subjectPrimary sclerosing cholangitisen
dc.subjectRelative survivalen
dc.subjectTransplant-free survivalen
dc.titleEpidemiology and outcomes of primary sclerosing cholangitis: an Australian multicentre retrospective cohort study.en
dc.typeJournal Articleen_US
dc.identifier.journaltitleHepatology Internationalen
dc.identifier.affiliationGastroenterology Department, Eastern Health, Melbourne, Australiaen
dc.identifier.affiliationUniversity of Melbourne, Melbourne, Australiaen
dc.identifier.affiliationGastroenterology and Hepatology Department, Western Health, Melbourne, Australiaen
dc.identifier.affiliationGastroenterology and Hepatology Department, Royal Adelaide Hospital, Adelaide, Australiaen
dc.identifier.affiliationGastroenterology and Hepatology Department, The Alfred Hospital, 55 Commercial Rd, Melbourne, 3004, Australiaen
dc.identifier.affiliationMonash University, Melbourne, Australiaen
dc.identifier.affiliationGastroenterology Department, Monash Health, Melbourne, Australiaen
dc.identifier.affiliationGastroenterology and Hepatologyen
dc.identifier.affiliationGastroenterology and Hepatology Department, St Vincent's Health, Melbourne, Australiaen
dc.identifier.affiliationAW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Sydney, Australiaen
dc.identifier.affiliationGastroenterology and Hepatology Department, Melbourne Health, Melbourne, Australiaen
dc.identifier.pubmedid35657479-, Abraham Samuel
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.openairecristype and Hepatology- and Sleep Medicine- (University of Melbourne)- Liver Transplant Unit-
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