Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/30849
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dc.contributor.authorLiu, Zhengyang-
dc.contributor.authorKaramesinis, Alexandra D-
dc.contributor.authorPlummer, Mark-
dc.contributor.authorSegal, Reny-
dc.contributor.authorBellomo, Rinaldo-
dc.contributor.authorSmith, Julian A-
dc.contributor.authorPerry, Luke A-
dc.date2022-
dc.date.accessioned2022-09-06T06:51:27Z-
dc.date.available2022-09-06T06:51:27Z-
dc.date.issued2022-09-
dc.identifier.citationBritish Journal of Anaesthesia 2022; 129(3): 366-377en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/30849-
dc.description.abstractThe epidemiology of persistent postoperative opioid use at least 3 months after cardiac surgery is poorly characterised despite its potential public health importance. We searched MEDLINE, Embase, and Google Scholar from inception to December 2021 and included studies reporting the rate and risk factors of persistent postoperative opioid use after cardiac surgery in opioid-naive and opioid-exposed patients. We recorded incidence rates and odds ratios (ORs) with 95% confidence intervals (CIs) for risk factors from individual studies and used random-effects inverse variance modelling to generate pooled estimates. From 10 studies involving 112 298 patients, the pooled rate of persistent postoperative opioid use in opioid-naive patients was 5.7% (95% CI: 4.2-7.2%). Risk factors included female sex (OR 1.18; 95% CI: 1.09-1.29), smoking (OR 1.34; 95% CI: 1.06-1.69), alcohol use (OR 1.43; 95% CI: 1.17-1.76), congestive cardiac failure (OR 1.17; 95% CI: 1.08-1.27), diabetes mellitus (OR 1.21; 95% CI: 1.07-1.37), chronic lung disease (OR 1.42; 95% CI: 1.16-1.75), chronic kidney disease (OR 1.35; 95% CI: 1.08-1.68), and length of hospital stay (per day) (OR 1.03; 95% CI: 1.02-1.04). Persistent postoperative opioid use after cardiac surgery affects at least one in 20 patients. The identification of risk factors, such as female sex, smoking, alcohol use, congestive cardiac failure, diabetes mellitus, chronic lung disease, chronic kidney disease, and length of hospital stay, should help target interventions aimed at decreasing its prevalence.en
dc.language.isoeng
dc.subjectcardiac surgeryen
dc.subjectmeta-analysisen
dc.subjectopioid analgesicsen
dc.subjectpersistent opioid useen
dc.subjectpostoperative painen
dc.subjectsystematic reviewen
dc.titleEpidemiology of persistent postoperative opioid use after cardiac surgery: a systematic review and meta-analysis.en
dc.typeJournal Articleen
dc.identifier.journaltitleBritish Journal of Anaesthesiaen
dc.identifier.affiliationData Analytics Research and Evaluation (DARE) Centreen
dc.identifier.affiliationAustralian and New Zealand Intensive Care Research Centre, Melbourne, VIC, Australia..en
dc.identifier.affiliationMonash University School and Public Health and Preventive Medicine, Monash University, Clayton, VIC, Australia..en
dc.identifier.affiliationDepartment of Anaesthesia, Peninsula Health, Frankston, VIC, Australia..en
dc.identifier.affiliationDepartment of Surgery (School of Clinical Sciences at Monash Health), Monash University, Clayton, VIC, Australia..en
dc.identifier.affiliationDepartment of Cardiothoracic Surgery, Monash Health, Clayton, VIC, Australia..en
dc.identifier.affiliationDepartment of Anaesthesia and Pain Management, Royal Melbourne Hospital, Parkville, VIC, Australia..en
dc.identifier.affiliationDepartment of Critical Care, Melbourne Medical School, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, VIC, Australia..en
dc.identifier.affiliationIntensive Care Unit, Royal Adelaide Hospital, Adelaide, SA, Australia..en
dc.identifier.affiliationIntensive Careen
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/35778278/en
dc.identifier.doi10.1016/j.bja.2022.05.026en
dc.type.contentTexten
dc.identifier.orcid0000-0002-1650-8939en
dc.identifier.pubmedid35778278
local.name.researcherBellomo, Rinaldo
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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