Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/30827
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dc.contributor.authorRoberts, Jason A-
dc.contributor.authorBellomo, Rinaldo-
dc.contributor.authorCotta, Menino O-
dc.contributor.authorKoch, Birgit C P-
dc.contributor.authorLyster, Haifa-
dc.contributor.authorOstermann, Marlies-
dc.contributor.authorRoger, Claire-
dc.contributor.authorShekar, Kiran-
dc.contributor.authorWatt, Kevin-
dc.contributor.authorAbdul-Aziz, Mohd H-
dc.date2022-
dc.date.accessioned2022-09-06T06:51:15Z-
dc.date.available2022-09-06T06:51:15Z-
dc.date.issued2022-08-23-
dc.identifier.citationIntensive Care Medicine 2022-10; 48(10): 1338-1351en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/30827-
dc.description.abstractIntensive care unit (ICU) patients with end-organ failure will require specialised machines or extracorporeal therapies to support the failing organs that would otherwise lead to death. ICU patients with severe acute kidney injury may require renal replacement therapy (RRT) to remove fluid and wastes from the body, and patients with severe cardiorespiratory failure will require extracorporeal membrane oxygenation (ECMO) to maintain adequate oxygen delivery whilst the underlying pathology is evaluated and managed. The presence of ECMO and RRT machines can further augment the existing pharmacokinetic (PK) alterations during critical illness. Significant changes in the apparent volume of distribution (Vd) and drug clearance (CL) for many important drugs have been reported during ECMO and RRT. Conventional antimicrobial dosing regimens rarely consider the impact of these changes and consequently, are unlikely to achieve effective antimicrobial exposures in critically ill patients receiving ECMO and/or RRT. Therefore, an in-depth understanding on potential PK changes during ECMO and/or RRT is required to inform antimicrobial dosing strategies in patients receiving ECMO and/or RRT. In this narrative review, we aim to discuss the potential impact of ECMO and RRT on the PK of antimicrobials and antimicrobial dosing requirements whilst receiving these extracorporeal therapies. The potential benefits of therapeutic drug monitoring (TDM) and dosing software to facilitate antimicrobial therapy for critically ill patients receiving ECMO and/or RRT are also reviewed and highlighted.en
dc.language.isoeng-
dc.subjectAntimicrobialen
dc.subjectDosing softwareen
dc.subjectExtracorporeal membrane oxygenationen
dc.subjectPharmacokineticsen
dc.subjectRenal replacement therapyen
dc.subjectTherapeutic drug monitoringen
dc.titleMachines that help machines to help patients: optimising antimicrobial dosing in patients receiving extracorporeal membrane oxygenation and renal replacement therapy using dosing software.en
dc.typeJournal Articleen
dc.identifier.journaltitleIntensive Care Medicineen
dc.identifier.affiliationDepartment of Intensive Care, Royal Melbourne Hospital, Melbourne, Australia..en
dc.identifier.affiliationFaculty of Medicine, University of Queensland Centre for Clinical Research (UQCCR), The University of Queensland, Brisbane, QLD, 4029, Australia..en
dc.identifier.affiliationAdult Intensive Care Services and Critical Care Research Group, The Prince Charles Hospital, Brisbane, QLD, Australia..en
dc.identifier.affiliationFaculty of Medicine, The University of Queensland, Brisbane, QLD, Australia..en
dc.identifier.affiliationFaculty of Health, Queensland University of Technology, Brisbane, QLD, Australia..en
dc.identifier.affiliationFaculty of Health Sciences and Medicine, Bond University, Gold Coast, QLD, Australia..en
dc.identifier.affiliationDepartment of Critical Care, The University of Melbourne, Melbourne, Australia..en
dc.identifier.affiliationAustralian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Australia..en
dc.identifier.affiliationIntensive Careen
dc.identifier.affiliationHerston Infectious Diseases (HeIDI), Metro North Health, Brisbane, QLD, Australia..en
dc.identifier.affiliationDepartment of Hospital Pharmacy, Erasmus University Medical Centre Rotterdam, Rotterdam, the Netherlands..en
dc.identifier.affiliationPharmacy Department, Royal Brompton and Harefield Hospitals, London, SW3 6NP, UK..en
dc.identifier.affiliationDepartment of Critical Care, King's College London, Guy's and St Thomas Hospital, London, SE1 7EH, UK..en
dc.identifier.affiliationDepartment of Anaesthesiology and Intensive Care, Pain and Emergency Medicine, Nîmes-Caremeau University Hospital, Place du Professeur Robert Debré, 30 029, Nîmes cedex 9, France..en
dc.identifier.affiliationSchool of Pharmacy, University of Waterloo, 10 Victoria St S. Kitchener, Waterloo, ON, N2G 1C5, Canada..en
dc.identifier.affiliationDepartment of Pharmacy and Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia..en
dc.identifier.affiliationDivision of Anaesthesiology Critical Care Emergency and Pain Medicine, Nîmes University Hospital, University of Montpellier, Nîmes, France..en
dc.identifier.affiliationCardiothoracic Transplant Unit, Royal Brompton and Harefield Hospitals, London, SW3 6NP, UK..en
dc.identifier.affiliationUR UM 103 IMAGINE, Faculty of Medicine, University of Montpellier, Nîmes, France..en
dc.identifier.affiliationDepartment of Paediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA..en
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/35997793/en
dc.identifier.doi10.1007/s00134-022-06847-2en
dc.type.contentTexten
dc.identifier.orcidhttp://orcid.org/0000-0001-6218-435Xen
dc.identifier.orcidhttp://orcid.org/0000-0002-1650-8939en
dc.identifier.pubmedid35997793-
local.name.researcherBellomo, Rinaldo
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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