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Title: Methamphetamine, amphetamine, and aggression in humans: A systematic review of drug administration studies.
Austin Authors: O'Malley, Kate Y;Hart, Carl L;Casey, Sharon;Downey, Luke A
Affiliation: Centre for Human Psychopharmacology, Swinburne University, 427-451 Burwood Road Hawthorn, Victoria, Australia 3122..
Department of Psychology, Columbia University, 1190 Amsterdam Avenue, 406 Schermerhorn, MC 5501, New York, NY 10027..
Centre for Human Psychopharmacology, Swinburne University, 427-451 Burwood Road Hawthorn, Victoria, Australia 3122..
Institute for Breathing and Sleep
Division on Substance Use, New York State Psychiatric Institute, and Department of Psychiatry, 1051 Riverside Drive, MC 120, New York, NY 10032..
Centre for Investigative Interviewing, Griffith, 176 Messines Ridge Road, Mount Gravatt, QLD, 4122..
Issue Date: 1-Aug-2022
Date: 2022
Publication information: Neuroscience and Biobehavioral Reviews 2022; 141: 104805
Abstract: The relationship between amphetamine use and aggressive or violent behaviour is unclear. This review examined laboratory data collected in humans, who were administered an acute dose of amphetamine or methamphetamine, in order to investigate the link between amphetamines and aggression. It is registered with PROSPERO (CRD42019127711). Included in the analysis are data from twenty-eight studies. Behavioural and/or subjective measures of aggression were assessed in one thousand and sixty-nine research participants, with limited amphetamine-use histories, following a single amphetamine dose (0-35mg). The available published evidence indicates that neither amphetamine nor methamphetamine acutely increased aggression as assessed by traditional laboratory measures. Future research should assess supratherapeutic amphetamine doses as well as include a broader range of multiple aggression measures, facilitating simultaneous assessment of the various components that comprise this complex, multifaceted construct.
DOI: 10.1016/j.neubiorev.2022.104805
ORCID: 0000-0001-5670-3192
Journal: Neuroscience and biobehavioral reviews
PubMed URL: 35926727
PubMed URL:
Type: Journal Article
Subjects: Methamphetamine
Appears in Collections:Journal articles

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