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dc.contributor.authorLarsen, Thomas-
dc.contributor.authorSee, Emily J-
dc.contributor.authorHolmes, Natasha E-
dc.contributor.authorBellomo, Rinaldo-
dc.identifier.citationNephrology (Carlton, Vic.) 2022; 27(7): 588-600en_US
dc.description.abstractBaseline serum creatinine values are required to diagnose acute kidney injury but are often unavailable. We evaluated four conventional equations to estimate creatinine. We then developed and validated a new equation corrected by age and gender. We retrospectively examined adults who, at first hospital admission, had available baseline creatinine data and developed acute kidney injury ≥24 h after admission. We split the study population: 50% (derivation) to develop a new linear equation and 50% (validation) to compare against conventional equations for bias, precision, and accuracy. We stratified analyses by age and gender. We studied 3139 hospitalized adults (58% male, median age 71). Conventional equations performed poorly in bias and accuracy in patients aged <60 or ≥75 (68% of the study population). The new linear equation had less bias and more accuracy. There were no clinically significant differences in precision. The median (95% confidence interval) difference in creatinine values estimated via the new equation minus measured baselines was 0.9 (-3.0, 5.9) and -0.5 (-7.0, 3.7) μmol/L in female patients 18-60 and 75-100, and -1.5 (-4.2, 2.2) and -7.8 (-12.7, -3.6) μmol/L in male patients 18-60 and 75-100, respectively. The new equation improved reclassification of KDIGO AKI stages compared to the MDRD II equation by 5.0%. Equations adjusted for age and gender are less biased and more accurate than unadjusted equations. Our new equation performed well in terms of bias, precision, accuracy, and reclassification.en_US
dc.subjectacute kidney injury/diagnosisen_US
dc.subjectacute kidney injury/epidemiologyen_US
dc.subjectage distributionen_US
dc.subjectlinear modelsen_US
dc.subjectsex distributionen_US
dc.titleEstimating baseline kidney function in hospitalized adults with acute kidney injury.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleNephrology (Carlton, Vic.)en_US
dc.identifier.affiliationData Analytics Research and Evaluation (DARE) Centreen_US
dc.identifier.affiliationIntensive Careen_US
dc.identifier.affiliationAustralian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia..en_US
dc.identifier.affiliationInfectious Diseasesen_US
dc.identifier.affiliationDepartment of Nephrology, Royal Melbourne Hospital, Melbourne, Victoria, Australia..en_US
dc.identifier.affiliationDepartment of Critical Care, University of Melbourne, Melbourne, Victoria, Australia..en_US
dc.identifier.affiliationDepartment of Intensive Care, Royal Melbourne Hospital, Parkville, Victoria, Australia..en_US
dc.identifier.pubmedid35471640, Rinaldo
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.grantfulltextnone- Care- Diseases- Analytics Research and Evaluation (DARE) Centre- Care- Analytics Research and Evaluation (DARE) Centre-
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