Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/30178
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dc.contributor.authorDe Gregorio, Michael-
dc.contributor.authorLee, Tanya-
dc.contributor.authorKrishnaprasad, Krupa-
dc.contributor.authorAmos, Gregory-
dc.contributor.authorAn, Yoon-Kyo-
dc.contributor.authorBastian-Jordan, Matthew-
dc.contributor.authorBegun, Jakob-
dc.contributor.authorBorok, Nira-
dc.contributor.authorBrown, Dougal J M-
dc.contributor.authorCheung, Wa-
dc.contributor.authorConnor, Susan J-
dc.contributor.authorGerstenmaier, Jan-
dc.contributor.authorGilbert, Lauren E-
dc.contributor.authorGilmore, Robert B-
dc.contributor.authorGu, Bonita-
dc.contributor.authorKutaiba, Numan-
dc.contributor.authorLee, Allan-
dc.contributor.authorMahy, Gillian-
dc.contributor.authorSrinivasan, Ashish-
dc.contributor.authorThin, Lena-
dc.contributor.authorThompson, Alexander J-
dc.contributor.authorWelman, Christopher J-
dc.contributor.authorYong, Eric X Z-
dc.contributor.authorDe Cruz, Peter P-
dc.contributor.authorvan Langenberg, Daniel-
dc.contributor.authorSparrow, Miles P-
dc.contributor.authorDing, Nik S-
dc.date2021-08-11-
dc.date.accessioned2022-06-23T00:26:26Z-
dc.date.available2022-06-23T00:26:26Z-
dc.date.issued2022-06-
dc.identifier.citationClinical gastroenterology and hepatology 2022; 20(6): 1306-1314en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/30178-
dc.description.abstractHigher anti-tumor necrosis factor-α (TNF) drug levels are associated with improved clinical healing of Crohn's perianal fistulas. It is unclear whether this leads to improved healing on radiologic assessment. We aimed to evaluate the association between anti-TNF drug levels and radiologic outcomes in perianal fistulising Crohn's disease. A cross-sectional retrospective multicenter study was undertaken. Patients with perianal fistulising Crohn's disease on maintenance infliximab or adalimumab, with drug levels within 6 months of perianal magnetic resonance imaging were included. Patients receiving dose changes or fistula surgery between drug level and imaging were excluded. Radiologic disease activity was scored using the Van Assche Index, with an inflammatory subscore calculated using indices: T2-weighted imaging hyperintensity, collections >3 mm diameter, rectal wall involvement. Primary endpoint was radiologic healing (inflammatory subscore ≤6). Secondary endpoint was radiologic remission (inflammatory subscore = 0). Of 193 patients (infliximab, n = 117; adalimumab, n = 76), patients with radiologic healing had higher median drug levels compared with those with active disease (infliximab 6.0 vs 3.9 μg/mL; adalimumab 9.1 vs 6.2 μg/mL; both P < .05). Patients with radiologic remission also had higher median drug levels compared with those with active disease (infliximab 7.4 vs 3.9 μg/mL; P < .05; adalimumab 9.8 vs 6.2 μg/mL; P = .07). There was a significant incremental reduction in median inflammatory subscores with higher anti-TNF drug level tertiles. Higher anti-TNF drug levels were associated with improved radiologic outcomes on magnetic resonance imaging in perianal fistulising Crohn's disease, with an incremental improvement at higher drug level tertiles for both infliximab and adalimumab.en_US
dc.language.isoeng
dc.subjectAnti-TNFen_US
dc.subjectCrohn’s Perianal Fistulaen_US
dc.subjectMagnetic Resonance Imagingen_US
dc.subjectTherapeutic Drug Monitoringen_US
dc.titleHigher Anti-tumor Necrosis Factor-α Levels Correlate With Improved Radiologic Outcomes in Crohn's Perianal Fistulas.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Associationen_US
dc.identifier.affiliationGastroenterology and Hepatologyen_US
dc.identifier.affiliationRadiologyen_US
dc.identifier.affiliationIngham Institute for Applied Medical Research, Medicine, Liverpool, Australia..en_US
dc.identifier.affiliationAlfred Health, Medical Imaging, Melbourne, Australia..en_US
dc.identifier.affiliationAlfred Health, Gastroenterology, Melbourne, Australia..en_US
dc.identifier.affiliationLiverpool Hospital, Medical Imaging, Liverpool, Australia..en_US
dc.identifier.affiliationLiverpool Hospital, Gastroenterology and Hepatology, Liverpool, Australia..en_US
dc.identifier.affiliationUniversity of New South Wales, South Western Sydney Clinical School, Sydney, Australia..en_US
dc.identifier.affiliationRoyal Prince Alfred Hospital, Gastroenterology and Hepatology, Camperdown, Australia..en_US
dc.identifier.affiliationEastern Health, Gastroenterology, Box Hill, Australia..en_US
dc.identifier.affiliationEastern Health, Radiology, Box Hill, Australia..en_US
dc.identifier.affiliationImaging Associates Eastern Health, Medical Imaging, Melbourne, Australia..en_US
dc.identifier.affiliationPeter MacCallum Cancer Centre, Cancer Imaging, Melbourne, Australia..en_US
dc.identifier.affiliationTownsville University Hospital, Gastroenterology, Douglas, Australia..en_US
dc.identifier.affiliationTownsville University Hospital, Medical Imaging, Douglas, Australia..en_US
dc.identifier.affiliationMonash University, Medicine, Clayton, Australia..en_US
dc.identifier.affiliationFiona Stanley Hospital, Gastroenterology, Murdoch, Australia..en_US
dc.identifier.affiliationFiona Stanley Hospital, Medical Imaging, Murdoch, Australia..en_US
dc.identifier.affiliationSt Vincent's Hospital Melbourne, Medical Imaging, Fitzroy, Australia..en_US
dc.identifier.affiliationSt Vincent's Hospital Melbourne, Department of Gastroenterology, Fitzroy, Australia..en_US
dc.identifier.affiliationUniversity of Melbourne, Medicine, Parkville, Australia..en_US
dc.identifier.affiliationUniversity of Western Australia, School of Medicine and Pharmacology, Crawley, Australia..en_US
dc.identifier.affiliationQIMR Berghofer Medical Research Institute, Gut Health Lab, Brisbane, Australia..en_US
dc.identifier.affiliationUniversity of Queensland, Medicine, St Lucia, Australia..en_US
dc.identifier.affiliationMater Hospital Brisbane, Gastroenterology, South Brisbane, Australia..en_US
dc.identifier.affiliationQueensland X-ray, Medical Imaging, Brisbane, Australia..en_US
dc.identifier.affiliationUniversity of Queensland, Mater Research Institute, St Lucia, Australia..en_US
dc.identifier.affiliationSouth Western Sydney Local Health District, Medicine, Liverpool, Australia..en_US
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/34389484/en_US
dc.identifier.doi10.1016/j.cgh.2021.07.053en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0002-3399-7236en_US
dc.identifier.orcid0000-0003-4627-9847en_US
dc.identifier.orcid0000-0001-5952-1570en_US
dc.identifier.pubmedid34389484
local.name.researcherDe Cruz, Peter P
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptGastroenterology and Hepatology-
crisitem.author.deptRadiology-
crisitem.author.deptGastroenterology and Hepatology-
crisitem.author.deptGastroenterology and Hepatology-
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