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https://ahro.austin.org.au/austinjspui/handle/1/28735
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DC Field | Value | Language |
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dc.contributor.author | Piotin, Anays | - |
dc.contributor.author | Godet, Julien | - |
dc.contributor.author | Trubiano, Jason | - |
dc.contributor.author | Grandbastien, Manon | - |
dc.contributor.author | Guénard-Bilbault, Lydie | - |
dc.contributor.author | de Blay, Frédéric | - |
dc.contributor.author | Metz-Favre, Carine | - |
dc.date | 2021-07-13 | - |
dc.date.accessioned | 2022-02-01T04:45:05Z | - |
dc.date.available | 2022-02-01T04:45:05Z | - |
dc.date.issued | 2022-01 | - |
dc.identifier.citation | Annals of Allergy, Asthma & Immunology 2022; 128(1): 27-32 | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/28735 | - |
dc.description.abstract | The challenge of delabeling amoxicillin allergy is an important issue for patients and clinicians, especially when anaphylaxis is reported. A recent study has proposed a clinical decision rule, PEN-FAST, to identify low-risk penicillin allergies. To validate the PEN-FAST clinical decision rule in a population with high risk of suspected immediate amoxicillin allergy and to identify clinical predictive factors of amoxicillin immediate hypersensitivity. We retrospectively analyzed medical records of patients with a suspected immediate amoxicillin allergy who carried out an allergologic evaluation by a specialist in the Allergy Unit of Strasbourg University Hospital from 2015 to 2020. A total of 142 adult patients (88 women [62.0%]; median age, 52 [interquartile range, 40.3-62.0] years) were analyzed. Most of them reported anaphylaxis (68.8%). Internal validation of PEN-FAST score revealed a good discrimination with area under the curve of 0.86 (95% confidence interval, 0.79-0.92). A cutoff of less than 3 points for PEN-FAST was used to classify 29 from 142 patients at low risk of allergy, of whom only 2 (6.9%) received positive results of allergy testing. The negative predictive value for successful delabeling was 0.93 (95% confidence interval, 0.77-0.99). Predictive clinical features for immediate amoxicillin hypersensitivity were time since reaction (P < .001), time elapsed between drug intake and first symptom (P < .001), severity grade reaction (P < .001), and treatment or hospitalization required (P < .001). PEN-FAST has been validated to identify low-risk penicillin allergies in our European cohort of patients mainly reporting anaphylaxis. This is the first reported external validation of a penicillin allergy clinical decision rule internationally. | en |
dc.language.iso | eng | - |
dc.title | Predictive factors of amoxicillin immediate hypersensitivity and validation of PEN-FAST clinical decision rule. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology | en |
dc.identifier.affiliation | Medicine (University of Melbourne) | en |
dc.identifier.affiliation | Infectious Diseases | en |
dc.identifier.affiliation | National Centre for Infections in Cancer, Peter MacCallum Cancer Centre, Parkville, Australia | en |
dc.identifier.affiliation | Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France | en |
dc.identifier.affiliation | Public Health Department, Strasbourg University Hospital, Strasbourg, France | en |
dc.identifier.affiliation | Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France | en |
dc.identifier.affiliation | Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, Strasbourg, France | en |
dc.identifier.affiliation | Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France | en |
dc.identifier.affiliation | Department of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, Australia | en |
dc.identifier.pubmeduri | https://pubmed.ncbi.nlm.nih.gov/34271183/ | en |
dc.identifier.doi | 10.1016/j.anai.2021.07.005 | en |
dc.type.content | Text | en |
dc.identifier.orcid | 0000-0002-5111-6367 | en |
dc.identifier.pubmedid | 34271183 | - |
local.name.researcher | Trubiano, Jason | - |
item.grantfulltext | none | - |
item.openairetype | Journal Article | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Infectious Diseases | - |
crisitem.author.dept | Medicine (University of Melbourne) | - |
crisitem.author.dept | Centre for Antibiotic Allergy and Research | - |
Appears in Collections: | Journal articles |
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