Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/28714
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dc.contributor.authorWalia, N-
dc.contributor.authorEratne, Dhamidhu-
dc.contributor.authorLoi, S M-
dc.contributor.authorLi, Q-X-
dc.contributor.authorVarghese, S-
dc.contributor.authorMalpas, C B-
dc.contributor.authorWalterfang, Mark-
dc.contributor.authorEvans, A H-
dc.contributor.authorParker, S-
dc.contributor.authorCollins, S J-
dc.contributor.authorMasters, C L-
dc.contributor.authorVelakoulis, D-
dc.date2021-
dc.date.accessioned2022-02-01T04:44:52Z-
dc.date.available2022-02-01T04:44:52Z-
dc.date.issued2022-01-15-
dc.identifier.citationJournal of the Neurological Sciences 2022; 432: 120088en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/28714-
dc.description.abstractDetermining disease severity and predicting prognosis in younger onset-dementia (YOD) remains challenging. Whether CSF biomarkers neurofilament light (NfL), tau and amyloidβ 42 (Aβ42) can help provide such information has been underexplored. Patients with YOD and CSF analysis were identified. We compared baseline NfL, tau and Aβ42 concentrations with contemporaneous Neuropsychiatry Unit Cognitive Assessment Tool (NUCOG) scores to assess their association with severity of cognitive impairment. Cognitive decline, as measured by longitudinal NUCOG assessment, was correlated against baseline biomarker levels to assess their utility in predicting the rate of cognitive decline. 78 patients with YOD (mean age = 56 years, SD = 8) and CSF analysis were identified. Dementia types included Alzheimer's disease, behavioural variant frontotemporal dementia, dementia not-otherwise-specified and other. Tau was associated with contemporaneous memory dysfunction (r = -0.556, 95% CI:[-0.702,-0.393], p < .001). 21 patients had longitudinal cognitive assessment up to 82 months from CSF sampling. NfL was associated with the rate of executive function decline (r = 0.755, 95% CI:[0.259,0.937], p < .001). Aβ42 was associated with the rate of memory decline (r = -0.582, 95% CI:[-0.855,-0.274], p = .007) and rate of total NUCOG decline (r = -0.515, 95% CI: [-0.809, -0.227], p = .017). CSF tau is related to contemporaneous memory impairment in YOD. NfL and Aβ42 levels are associated with the rate of executive function and memory decline, respectively, and may have a role in prognostication in YOD.en
dc.language.isoeng
dc.subjectCSF biomarkersen
dc.subjectCognitive declineen
dc.subjectNeurofilament lighten
dc.subjectTauen
dc.subjectYounger-onset dementiaen
dc.subjectamyloidβ 42en
dc.titleCerebrospinal fluid neurofilament light predicts the rate of executive function decline in younger-onset dementia.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of the Neurological Sciencesen
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Healthen
dc.identifier.affiliationNational Dementia and Diagnostics Laboratory, Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australiaen
dc.identifier.affiliationDepartment of Neurology, The Royal Melbourne Hospital, Parkville, VIC, Australiaen
dc.identifier.affiliationMelbourne Neuropsychiatry Centre & Department of Psychiatry, The University of Melbourne, Parkville, VIC, Australiaen
dc.identifier.affiliationDepartment of Medicine (RMH), The University of Melbourne, Parkville, VIC, Australiaen
dc.identifier.affiliationMelbourne Medical School, The University of Melbourne, Parkville, VIC, Australiaen
dc.identifier.affiliationClinical Outcomes Research Unit (CORe), Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC, Australiaen
dc.identifier.affiliationNeuropsychiatry, The Royal Melbourne Hospital, Parkville, VIC, Australiaen
dc.identifier.doi10.1016/j.jns.2021.120088en
dc.type.contentTexten
dc.identifier.orcid0000-0002-1389-3691en
dc.identifier.orcid0000-0002-3226-7645en
dc.identifier.orcid0000-0001-8438-3763en
dc.identifier.orcid0000-0002-5245-6611en
dc.identifier.orcid0000-0003-3072-7940en
dc.identifier.pubmedid34922179
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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