Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/28641
Title: STAT3 Signaling in Breast Cancer: Multicellular Actions and Therapeutic Potential.
Austin Authors: To, Sarah Q;Dmello, Rhynelle S;Richards, Anna K;Ernst, Matthias ;Chand, Ashwini L 
Affiliation: Olivia Newton-John Cancer Research Institute
School of Cancer Medicine, La Trobe University, Heidelberg, VIC 3084, Australia
Issue Date: 15-Jan-2022
Date: 2022
Publication information: Cancers 2022; 14(2): 429.
Abstract: Interleukin (IL)-6 family cytokines, such as IL-6 and IL-11, are defined by the shared use of the gp130 receptor for the downstream activation of STAT3 signaling and the activation of genes which contribute to the "hallmarks of cancer", including proliferation, survival, invasion and metastasis. Increased expression of these cytokines, or the ligand-specific receptors IL-6R and IL-11RA, in breast tumors positively correlate to disease progression and poorer patient outcome. In this review, we examine evidence from pre-clinical studies that correlate enhanced IL-6 and IL-11 mediated gp130/STAT3 signaling to the progression of breast cancer. Key processes by which the IL-6 family cytokines contribute to the heterogeneous nature of breast cancer, immune evasion and metastatic potential, are discussed. We examine the latest research into the therapeutic targeting of IL-6 family cytokines that inhibit STAT3 transcriptional activity as a potential breast cancer treatment, including current clinical trials. The importance of the IL-6 family of cytokines in cellular processes that promote the development and progression of breast cancer warrants further understanding of the molecular basis for its actions to help guide the development of future therapeutic targets.
URI: https://ahro.austin.org.au/austinjspui/handle/1/28641
DOI: 10.3390/cancers14020429
ORCID: 0000-0002-1245-729X
0000-0002-6399-1177
Journal: Cancers
PubMed URL: 35053592
PubMed URL: https://pubmed.ncbi.nlm.nih.gov/35053592/
ISSN: 2072-6694
Type: Journal Article
Subjects: IL-11
IL-6
STAT3
breast cancer
metastasis
targeted therapies
Appears in Collections:Journal articles

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