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dc.contributor.authorRay, Jason C-
dc.contributor.authorAllen, Penelope-
dc.contributor.authorBacsi, Ann-
dc.contributor.authorBosco, Julian J-
dc.contributor.authorChen, Luke-
dc.contributor.authorEller, Michael-
dc.contributor.authorKua, Hock-
dc.contributor.authorLim, Lyndell L-
dc.contributor.authorMatharu, Manjit S-
dc.contributor.authorMonif, Mastura-
dc.contributor.authorRuttledge, Martin-
dc.contributor.authorStark, Richard J-
dc.contributor.authorHutton, Elspeth J-
dc.identifier.citationThe Journal of Headache and Pain 2021; 22(1): 121en
dc.description.abstractCalcitonin gene-related peptide (CGRP) is expressed throughout the body and is a known mediator of migraine, exerting this biological effect through activation of trigeminovascular, meningeal and associated neuronal pathways located in close proximity to the central nervous system. Monoclonal antibodies (mAb) targeting the CGRP pathway are an effective new preventive treatment for migraine, with a generally favourable adverse event profile. Pre-clinical evidence supports an anti-inflammatory/immunoregulatory role for CGRP in other organ systems, and therefore inhibition of the normal action of this peptide may promote a pro-inflammatory response. We present a case series of eight patients with new or significantly worsened inflammatory pathology in close temporal association with the commencement of CGRP mAb therapy. This case series provides novel insights on the potential molecular mechanisms and side-effects of CGRP antagonism in migraine and supports clinical vigilance in patient care going forward.en
dc.subjectAutoimmune diseasesen
dc.subjectCGRP receptor antagonistsen
dc.subjectDrug-related side effects and adverse reactionsen
dc.subjectMonoclonal antibodiesen
dc.titleInflammatory complications of CGRP monoclonal antibodies: a case series.en
dc.typeJournal Articleen
dc.identifier.journaltitleThe Journal of Headache and Painen
dc.identifier.affiliationDepartment of Allergy, asthma and clinical immunology, Alfred Hospital, Commercial Road 3004, Melbourne, Australiaen
dc.identifier.affiliationDepartment of Surgery (Ophthalmology), University of Melbourne, Parkville, Australiaen
dc.identifier.affiliationCentre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australiaen
dc.identifier.affiliationDepartment of Neurology, Alfred Hospital, Commercial Melbourne 3004, Melbourne, Australiaen
dc.identifier.affiliationOtoneurology Diagnostic Unit, Alfred Hospital, Commercial Rd 3004, Melbourne, VIC, Australiaen
dc.identifier.affiliationDepartment of Neuroscience, Monash University, Vic, Melbourne, 3004, Australiaen
dc.identifier.affiliationIntegrated Specialist Medical Care, Sydney, Australiaen
dc.identifier.affiliationCentral Clinical School, Faculty of Medicine Nursing and Health Sciences, Monash University, Melbourne, Australiaen
dc.identifier.affiliationDepartment of Neurology, Monash Medical Centre, Vic, Melbourne, Australiaen
dc.identifier.affiliationSchool of Clinical Sciences, Monash University, Vic, Melbourne, Australiaen
dc.identifier.affiliationDepartment of Pathology, Monash Medical Centre, Vic, Melbourne, Australiaen
dc.identifier.affiliationDepartment of Neurology, Royal Melbourne Hospital, Vic, Parkville, 3050, Australiaen
dc.identifier.affiliationMS and Neuroimmunology Department, Alfred Hospital, Vic, Melbourne, 3004, Australiaen
dc.identifier.affiliationUniversity College London (UCL) Queen Square Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, University College London, Gower Street WC1E 6BT, London, UKen
dc.identifier.affiliationConsultant Neurologist & Headache Clinical Lead, Beaumont Hospital, Beaumont Road, Dublin, Irelanden
dc.identifier.pubmedid34625019-, Jason C
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
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