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https://ahro.austin.org.au/austinjspui/handle/1/27079
Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Ong, Sim Yee | - |
dc.contributor.author | Khoo, Tiffany | - |
dc.contributor.author | Nicoll, Amanda J | - |
dc.contributor.author | Gurrin, Lyle | - |
dc.contributor.author | Worland, Thomas | - |
dc.contributor.author | Pateria, Puraskar | - |
dc.contributor.author | Ramm, Louise E | - |
dc.contributor.author | Testro, Adam G | - |
dc.contributor.author | Anderson, Gregory J | - |
dc.contributor.author | Skoien, Richard | - |
dc.contributor.author | Powell, Lawrie W | - |
dc.contributor.author | Ramm, Grant A | - |
dc.contributor.author | Olynyk, John K | - |
dc.contributor.author | Delatycki, Martin B | - |
dc.date | 2021-07-19 | - |
dc.date.accessioned | 2021-07-26T05:07:02Z | - |
dc.date.available | 2021-07-26T05:07:02Z | - |
dc.date.issued | 2021-07-19 | - |
dc.identifier.citation | Scientific Reports 2021; 11(1): 14654 | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/27079 | - |
dc.description.abstract | Aspartate aminotransferase-to-platelet ratio index (APRI) and Fibrosis-4 Index (Fib4) have been validated against liver biopsy for detecting advanced hepatic fibrosis in HFE hemochromatosis. We determined the diagnostic utility for advanced hepatic fibrosis of Hepascore and transient elastography compared with APRI and Fib4 in 134 newly diagnosed HFE hemochromatosis subjects with serum ferritin levels > 300 µg/L using area under the receiver operator characteristic curve (AUROC) analysis and APRI- (> 0.44) or Fib4- (> 1.1) cut-offs for AHF, or a combination of both. Compared with APRI, Hepascore demonstrated an AUROC for advanced fibrosis of 0.69 (95% CI 0.56-0.83; sensitivity = 69%, specificity = 65%; P = 0.01) at a cut-off of 0.22. Using a combination of APRI and Fib4, the AUROC for Hepascore for advanced fibrosis was 0.70 (95% CI 0.54-0.86, P = 0.02). Hepascore was not diagnostic for detection of advanced fibrosis using the Fib4 cut-off. Elastography was not diagnostic using either APRI or Fib4 cut-offs. Hepascore and elastography detected significantly fewer true positive or true negative cases of advanced fibrosis compared with APRI and Fib4, except in subjects with serum ferritin levels > 1000 µg/L. In comparison with APRI or Fib4, Hepascore or elastography may underdiagnose advanced fibrosis in HFE Hemochromatosis, except in individuals with serum ferritin levels > 1000 µg/L. | en |
dc.language.iso | eng | - |
dc.title | Utility and limitations of Hepascore and transient elastography to detect advanced hepatic fibrosis in HFE hemochromatosis. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | Scientific Reports | en |
dc.identifier.affiliation | Victorian Clinical Genetics Services, Parkville, VIC, Australia | en |
dc.identifier.affiliation | Department of Gastroenterology, Royal Brisbane and Women's Hospital, Herston, QLD, Australia | en |
dc.identifier.affiliation | School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia | en |
dc.identifier.affiliation | Bruce Lefroy Centre, Murdoch Children's Research Institute, Melbourne, VIC, Australia | en |
dc.identifier.affiliation | The University of Melbourne, Melbourne, VIC, Australia | en |
dc.identifier.affiliation | Department of Gastroenterology, Eastern Health, Box Hill, Victoria, Australia | en |
dc.identifier.affiliation | Department of Gastroenterology, Fiona Stanley Hospital, Murdoch, WA, Australia | en |
dc.identifier.affiliation | Monash University, Melbourne, VIC, Australia | en |
dc.identifier.affiliation | Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Carlton, VIC, Australia | en |
dc.identifier.affiliation | Hepatic Fibrosis Group, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia | en |
dc.identifier.affiliation | Gastroenterology and Hepatology | en |
dc.identifier.affiliation | Iron Metabolism Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia | en |
dc.identifier.affiliation | Faculty of Medicine, The University of Queensland, Brisbane, Australia | en |
dc.identifier.doi | 10.1038/s41598-021-94083-x | en |
dc.type.content | Text | en |
dc.identifier.pubmedid | 34282177 | - |
local.name.researcher | Delatycki, Martin B | |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.openairetype | Journal Article | - |
crisitem.author.dept | Gastroenterology and Hepatology | - |
crisitem.author.dept | Victorian Liver Transplant Unit | - |
crisitem.author.dept | Gastroenterology and Hepatology | - |
crisitem.author.dept | Clinical Genetics | - |
Appears in Collections: | Journal articles |
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