Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/27079
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dc.contributor.authorOng, Sim Yee-
dc.contributor.authorKhoo, Tiffany-
dc.contributor.authorNicoll, Amanda J-
dc.contributor.authorGurrin, Lyle-
dc.contributor.authorWorland, Thomas-
dc.contributor.authorPateria, Puraskar-
dc.contributor.authorRamm, Louise E-
dc.contributor.authorTestro, Adam G-
dc.contributor.authorAnderson, Gregory J-
dc.contributor.authorSkoien, Richard-
dc.contributor.authorPowell, Lawrie W-
dc.contributor.authorRamm, Grant A-
dc.contributor.authorOlynyk, John K-
dc.contributor.authorDelatycki, Martin B-
dc.date2021-07-19-
dc.date.accessioned2021-07-26T05:07:02Z-
dc.date.available2021-07-26T05:07:02Z-
dc.date.issued2021-07-19-
dc.identifier.citationScientific Reports 2021; 11(1): 14654en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/27079-
dc.description.abstractAspartate aminotransferase-to-platelet ratio index (APRI) and Fibrosis-4 Index (Fib4) have been validated against liver biopsy for detecting advanced hepatic fibrosis in HFE hemochromatosis. We determined the diagnostic utility for advanced hepatic fibrosis of Hepascore and transient elastography compared with APRI and Fib4 in 134 newly diagnosed HFE hemochromatosis subjects with serum ferritin levels > 300 µg/L using area under the receiver operator characteristic curve (AUROC) analysis and APRI- (> 0.44) or Fib4- (> 1.1) cut-offs for AHF, or a combination of both. Compared with APRI, Hepascore demonstrated an AUROC for advanced fibrosis of 0.69 (95% CI 0.56-0.83; sensitivity = 69%, specificity = 65%; P = 0.01) at a cut-off of 0.22. Using a combination of APRI and Fib4, the AUROC for Hepascore for advanced fibrosis was 0.70 (95% CI 0.54-0.86, P = 0.02). Hepascore was not diagnostic for detection of advanced fibrosis using the Fib4 cut-off. Elastography was not diagnostic using either APRI or Fib4 cut-offs. Hepascore and elastography detected significantly fewer true positive or true negative cases of advanced fibrosis compared with APRI and Fib4, except in subjects with serum ferritin levels > 1000 µg/L. In comparison with APRI or Fib4, Hepascore or elastography may underdiagnose advanced fibrosis in HFE Hemochromatosis, except in individuals with serum ferritin levels > 1000 µg/L.en
dc.language.isoeng-
dc.titleUtility and limitations of Hepascore and transient elastography to detect advanced hepatic fibrosis in HFE hemochromatosis.en
dc.typeJournal Articleen
dc.identifier.journaltitleScientific Reportsen
dc.identifier.affiliationVictorian Clinical Genetics Services, Parkville, VIC, Australiaen
dc.identifier.affiliationDepartment of Gastroenterology, Royal Brisbane and Women's Hospital, Herston, QLD, Australiaen
dc.identifier.affiliationSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australiaen
dc.identifier.affiliationBruce Lefroy Centre, Murdoch Children's Research Institute, Melbourne, VIC, Australiaen
dc.identifier.affiliationThe University of Melbourne, Melbourne, VIC, Australiaen
dc.identifier.affiliationDepartment of Gastroenterology, Eastern Health, Box Hill, Victoria, Australiaen
dc.identifier.affiliationDepartment of Gastroenterology, Fiona Stanley Hospital, Murdoch, WA, Australiaen
dc.identifier.affiliationMonash University, Melbourne, VIC, Australiaen
dc.identifier.affiliationCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Carlton, VIC, Australiaen
dc.identifier.affiliationHepatic Fibrosis Group, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australiaen
dc.identifier.affiliationGastroenterology and Hepatologyen
dc.identifier.affiliationIron Metabolism Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australiaen
dc.identifier.affiliationFaculty of Medicine, The University of Queensland, Brisbane, Australiaen
dc.identifier.doi10.1038/s41598-021-94083-xen
dc.type.contentTexten
dc.identifier.pubmedid34282177-
local.name.researcherDelatycki, Martin B
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptGastroenterology and Hepatology-
crisitem.author.deptVictorian Liver Transplant Unit-
crisitem.author.deptGastroenterology and Hepatology-
crisitem.author.deptClinical Genetics-
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