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dc.contributor.authorModra, Lucy J-
dc.contributor.authorHiggins, Alisa-
dc.contributor.authorVithanage, Ruvini-
dc.contributor.authorAbeygunawardana, Vihangi-
dc.contributor.authorBailey, Michael-
dc.contributor.authorBellomo, Rinaldo-
dc.identifier.citationJournal of Critical Care 2021; 65: 116-123en
dc.description.abstractTo investigate the association between sex and illness severity and mortality of ICU patients. We performed systematic searches of MEDLINE and EMBASE for observational studies of adult ICU patients that explicitly examined the association between sex and illness severity or mortality. We used a random effects model to calculate standardised mean differences in illness severity scores and pooled odds ratios for mortality of women compared to men. We identified 21 studies with 505,138 participants in total (43.1% women). There was substantial heterogeneity among studies. Only two studies were at low risk of bias overall. At ICU admission, there was a pattern of higher illness severity scores among women (standardised mean difference 0.04, 95% CI -0.01-0.09). Women had higher risk-adjusted mortality than men at ICU discharge (OR 1.25 95% CI 1.03-1.50) and 1 year (OR 1.08, 95% CI 1.02-1.13), however this finding was not robust to sensitivity analysis. Women tend to have higher illness severity scores at ICU admission. Women also appear to have higher risk-adjusted mortality than men at ICU discharge and at 1 year. Given the heterogeneity and risk of bias in the existing literature, additional studies are needed to confirm or refute these findings.en
dc.subjectIllness severityen
dc.subjectIntensive careen
dc.titleSex differences in illness severity and mortality among adult intensive care patients: A systematic review and meta-analysis.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Critical Careen
dc.identifier.affiliationDepartment of Intensive Care, Monash Health, VIC, Australiaen
dc.identifier.affiliationCentre for Integrated Critical Care, University of Melbourne, Melbourne, VIC, Australiaen
dc.identifier.affiliationDepartment of Intensive Care, Royal Melbourne Hospital, Melbourne, VIC, Australiaen
dc.identifier.affiliationAustralia and New Zealand Intensive Care Research Centre, School of Public Health and Preventative Medicine, Monash University, Melbourne, VIC, Australiaen
dc.identifier.affiliationIntensive Careen
dc.identifier.pubmedid34118502-, Rinaldo
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.grantfulltextnone- Care- Care- Analytics Research and Evaluation (DARE) Centre-
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