Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/26594
Full metadata record
DC FieldValueLanguage
dc.contributor.authorRoberts, Jason A-
dc.contributor.authorJoynt, Gavin M-
dc.contributor.authorLee, Anna-
dc.contributor.authorChoi, Gordon-
dc.contributor.authorBellomo, Rinaldo-
dc.contributor.authorKanji, Salmaan-
dc.contributor.authorMudaliar, M Yugan-
dc.contributor.authorPeake, Sandra L-
dc.contributor.authorStephens, Dianne-
dc.contributor.authorTaccone, Fabio Silvio-
dc.contributor.authorUlldemolins, Marta-
dc.contributor.authorValkonen, Miia Maaria-
dc.contributor.authorAgbeve, Julius-
dc.contributor.authorBaptista, João P-
dc.contributor.authorBekos, Vasileios-
dc.contributor.authorBoidin, Clement-
dc.contributor.authorBrinkmann, Alexander-
dc.contributor.authorBuizen, Luke-
dc.contributor.authorCastro, Pedro-
dc.contributor.authorCole, C Louise-
dc.contributor.authorCreteur, Jacques-
dc.contributor.authorDe Waele, Jan J-
dc.contributor.authorDeans, Renae-
dc.contributor.authorEastwood, Glenn M-
dc.contributor.authorEscobar, Leslie-
dc.contributor.authorGomersall, Charles-
dc.contributor.authorGresham, Rebecca-
dc.contributor.authorJamal, Janattul Ain-
dc.contributor.authorKluge, Stefan-
dc.contributor.authorKönig, Christina-
dc.contributor.authorKoulouras, Vasilios P-
dc.contributor.authorLassig-Smith, Melissa-
dc.contributor.authorLaterre, Pierre-Francois-
dc.contributor.authorLei, Katie-
dc.contributor.authorLeung, Patricia-
dc.contributor.authorLefrant, Jean-Yves-
dc.contributor.authorLlauradó-Serra, Mireia-
dc.contributor.authorMartin-Loeches, Ignacio-
dc.contributor.authorMat Nor, Mohd Basri-
dc.contributor.authorOstermann, Marlies-
dc.contributor.authorParker, Suzanne L-
dc.contributor.authorRello, Jordi-
dc.contributor.authorRoberts, Darren M-
dc.contributor.authorRoberts, Michael S-
dc.contributor.authorRichards, Brent-
dc.contributor.authorRodríguez, Alejandro-
dc.contributor.authorRoehr, Anka C-
dc.contributor.authorRoger, Claire-
dc.contributor.authorSeoane, Leonardo-
dc.contributor.authorSinnollareddy, Mahipal-
dc.contributor.authorSousa, Eduardo-
dc.contributor.authorSoy, Dolors-
dc.contributor.authorSpring, Anna-
dc.contributor.authorStarr, Therese-
dc.contributor.authorThomas, Jane-
dc.contributor.authorTurnidge, John-
dc.contributor.authorWallis, Steven C-
dc.contributor.authorWilliams, Tricia-
dc.contributor.authorWittebole, Xavier-
dc.contributor.authorZikou, Xanthi T-
dc.contributor.authorPaul, Sanjoy K-
dc.contributor.authorLipman, Jeffrey-
dc.date.accessioned2021-05-24T05:45:36Z-
dc.date.available2021-05-24T05:45:36Z-
dc.date.issued2021-
dc.identifier.citationClinical Infectious Diseases 2021; 72(8): 1369-1378en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/26594-
dc.description.abstractThe optimal dosing of antibiotics in critically ill patients receiving renal replacement therapy (RRT) remains unclear. In this study, we describe the variability in RRT techniques and antibiotic dosing in critically ill patients receiving RRT and relate observed trough antibiotic concentrations to optimal targets. We performed a prospective, observational, multinational, pharmacokinetic study in 29 intensive care units from 14 countries. We collected demographic, clinical, and RRT data. We measured trough antibiotic concentrations of meropenem, piperacillin-tazobactam, and vancomycin and related them to high- and low-target trough concentrations. We studied 381 patients and obtained 508 trough antibiotic concentrations. There was wide variability (4-8-fold) in antibiotic dosing regimens, RRT prescription, and estimated endogenous renal function. The overall median estimated total renal clearance (eTRCL) was 50 mL/minute (interquartile range [IQR], 35-65) and higher eTRCL was associated with lower trough concentrations for all antibiotics (P < .05). The median (IQR) trough concentration for meropenem was 12.1 mg/L (7.9-18.8), piperacillin was 78.6 mg/L (49.5-127.3), tazobactam was 9.5 mg/L (6.3-14.2), and vancomycin was 14.3 mg/L (11.6-21.8). Trough concentrations failed to meet optimal higher limits in 26%, 36%, and 72% and optimal lower limits in 4%, 4%, and 55% of patients for meropenem, piperacillin, and vancomycin, respectively. In critically ill patients treated with RRT, antibiotic dosing regimens, RRT prescription, and eTRCL varied markedly and resulted in highly variable antibiotic concentrations that failed to meet therapeutic targets in many patients.en
dc.language.isoeng
dc.subjectbeta-lactamen
dc.subjectcontinuous renal replacement therapyen
dc.subjectextended daily dialysisen
dc.subjectpharmacokineticen
dc.subjectrenal clearanceen
dc.titleThe Effect of Renal Replacement Therapy and Antibiotic Dose on Antibiotic Concentrations in Critically Ill Patients: Data From the Multinational Sampling Antibiotics in Renal Replacement Therapy Study.en
dc.typeJournal Articleen
dc.identifier.journaltitleClinical Infectious Diseasesen
dc.identifier.affiliationDepartment of Nursing, School of Medicine and Health Sciences, Universitat Internacional de Catalunya, Barcelona, Spainen
dc.identifier.affiliationHôpital Pierre Garraud, Hospices Civils de Lyon, Lyon, Franceen
dc.identifier.affiliationIntensive Care Services, Royal Brisbane and Women's Hospital, Brisbane, Australiaen
dc.identifier.affiliationPharmacy Department, Royal Brisbane and Women's Hospital, Brisbane, Australiaen
dc.identifier.affiliationCentre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, Queensland, Australiaen
dc.identifier.affiliationIntensive Care Unit, Westmead Hospital, Sydney, Australiaen
dc.identifier.affiliationMedical School, University of Sydney, Sydney, Australiaen
dc.identifier.affiliationDepartment of Intensive Care Medicine, The Queen Elizabeth Hospital, Woodville, Australiaen
dc.identifier.affiliationSchool of Medicine, University of Adelaide, Adelaide, Australiaen
dc.identifier.affiliationSchool of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australiaen
dc.identifier.affiliationIntensive Care Unit, Royal Darwin Hospital, Darwin, Australiaen
dc.identifier.affiliationFlinders University, Adelaide, Australiaen
dc.identifier.affiliationNational Critical Care and Trauma Response Centre, Darwin, Australiaen
dc.identifier.affiliationSchool of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australiaen
dc.identifier.affiliationTherapeutics Research Centre, Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, Adelaide, Australiaen
dc.identifier.affiliationTranslational Research Institute, The University of Queensland, Buranda, Australiaen
dc.identifier.affiliationMelbourne EpiCentre, University of Melbourne and Melbourne Health, Melbourne, Australiaen
dc.identifier.affiliationIntensive Care Unit, Gold Coast University Hospital, Gold Coast, Australiaen
dc.identifier.affiliationIntensive Careen
dc.identifier.affiliationClinical Trials and Biostatistics Unit, QIMR Berghofer Medical Research Institute, Herston, Australiaen
dc.identifier.affiliationIntensive Care Unit, Ochsner Health System, New Orleans, Louisiana, USAen
dc.identifier.affiliationThe Ottawa Hospital Research Institute, Ottawa, Canadaen
dc.identifier.affiliationInfectious Diseases-Internal Medicine Departments, Bellvitge University Hospital, l'Hospitalet de Llobregat, Spainen
dc.identifier.affiliationRovira i Virgili University, IISPV/CIBERES, Tarragona, Spainen
dc.identifier.affiliationPharmacy Department, Division of Medicines. Hospital Clínic de Barcelona, Barcelona, Spainen
dc.identifier.affiliationCIBERES, Vall d'Hebron Institute of Research, Barcelona, Spainen
dc.identifier.affiliationIntensive Care Unit, Nepean Hospital, Sydney, Australiaen
dc.identifier.affiliationIDIBAPS, University of Barcelona, Barcelona, Spainen
dc.identifier.affiliationFaculty of Medicine, An University of Queensland, New Orleans, Louisiana, USAen
dc.identifier.affiliationIntensive Care Unit, University Hospital Joan XXIII, Tarragona, Spainen
dc.identifier.affiliationCritical Care Department, Corporació Sanitària Parc Taulí, Sabadell, Spainen
dc.identifier.affiliationMultidisciplinary Intensive Care Research Organization (MICRO), St James Hospital, Dublin, Irelanden
dc.identifier.affiliationMedical Intensive Care Unit, ICMiD. Hospital Clínic de Barcelona, Barcelona, Spainen
dc.identifier.affiliationThe University of Queensland Centre for Clinical Research, The University of Queensland, Brisbane, Queensland, Australiaen
dc.identifier.affiliationUniversité Claude Bernard Lyon 1, UMR CNRS 5558, Laboratoire de Biométrie et Biologie Évolutive, Lyon, Franceen
dc.identifier.affiliationFundació Privada Clínic per la Recerca Biomèdica, Barcelona, Spainen
dc.identifier.affiliationDepartment of Pharmacy, The Ottawa Hospital, Ottawa, Canadaen
dc.identifier.affiliationDepartment of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germanyen
dc.identifier.affiliationHospital Pharmacy, University Medical Centre Hamburg-Eppendorf, Hamburg, Germanyen
dc.identifier.affiliationDepartment of Pharmacy, General Hospital of Heidenheim, Heidenheim, Germanyen
dc.identifier.affiliationDepartment of Anesthesia and Critical Care Medicine, General Hospital of Heidenheim, Heidenheim, Germanyen
dc.identifier.affiliationDepartment of Anesthesia and Intensive Care, The Chinese University of Hong Kong, Shatin, Hong Kongen
dc.identifier.affiliationDepartment of Intensive Care, Erasme Hospital, Brussels, Belgiumen
dc.identifier.affiliationIntensive Care Medicine, Department of Perioperative, Intensive Care, and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finlanden
dc.identifier.affiliationIntensive Care Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugalen
dc.identifier.affiliationIntensive Care Unit, Naval and Veterans Hospital of Athens, Athens, Greeceen
dc.identifier.affiliationDepartment of Intensive Care, Erasme Hospital, Brussels, Belgiumen
dc.identifier.affiliationDepartment of Critical Care Medicine; Ghent University Hospital, Ghent, Belgiumen
dc.identifier.affiliationFaculty of Medicine, Universidad de Chile, Santiago, Chileen
dc.identifier.affiliationDepartment of Anesthesia and Intensive Care, The Chinese University of Hong Kong, Shatin, Hong Kongen
dc.identifier.affiliationDepartment of Pharmacy, Hospital Tengku Ampuan Afzan, Kuantan, Pahang, Malaysiaen
dc.identifier.affiliationIntensive Care Unit Department, University Hospital of Ioannina, Ioannina, Greeceen
dc.identifier.affiliationIntensive Care Unit, Clinique Universitaire St Luc UCL, Brussels, Belgiumen
dc.identifier.affiliationGuy's and St Thomas Hospital, London, United Kingdomen
dc.identifier.affiliationDepartment of Anesthesia and Intensive Care, The Chinese University of Hong Kong, Shatin, Hong Kongen
dc.identifier.affiliationIntensive Care Unit, Nîmes University Hospital (Centre Hospitalo Universitaire Nimes), Nimes, Franceen
dc.identifier.affiliationDepartment of Anesthesiology and Intensive Care, School of Medicine, International Islamic University Malaysia, Selangor, Malaysiaen
dc.identifier.affiliationGuy's and St Thomas Hospital, London, United Kingdomen
dc.identifier.affiliationIntensive Care Unit, Nîmes University Hospital (Centre Hospitalo Universitaire Nimes), Nimes, Franceen
dc.identifier.affiliationIntensive Care Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugalen
dc.identifier.affiliationIntensive Care Unit, Naval and Veterans Hospital of Athens, Athens, Greeceen
dc.identifier.affiliationIntensive Care Unit, Clinique Universitaire St Luc UCL, Brussels, Belgiumen
dc.identifier.affiliationNephrology, University Hospital of Ioannina, Ioannina, Greeceen
dc.identifier.affiliationSchool of Medicine, The University of Melbourne, Melbourne, Australiaen
dc.identifier.doi10.1093/cid/ciaa224en
dc.type.contentTexten
dc.identifier.pubmedid32150603
Appears in Collections:Journal articles
Show simple item record

Page view(s)

12
checked on Jul 2, 2021

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.