Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/25919
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dc.contributor.authorCopaescu, Ana-
dc.contributor.authorGibson, Andrew-
dc.contributor.authorLi, Yueran-
dc.contributor.authorTrubiano, Jason-
dc.contributor.authorPhillips, Elizabeth J-
dc.date2021-
dc.date.accessioned2021-02-22T23:52:01Z-
dc.date.available2021-02-22T23:52:01Z-
dc.date.issued2020-01-12-
dc.identifier.citationFrontiers in Pharmacology 2020; 11: 573573en_US
dc.identifier.issn1663-9812-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/25919-
dc.description.abstractDelayed drug hypersensitivity reactions are clinically diverse reactions that vary from isolated benign skin conditions that remit quickly with no or symptomatic treatment, drug discontinuation or even continued drug treatment, to the other extreme of severe cutaneous adverse reactions (SCARs) that are associated with presumed life-long memory T-cell responses, significant acute and long-term morbidity and mortality. Diagnostic "in clinic" approaches to delayed hypersensitivity reactions have included patch testing (PT), delayed intradermal testing (IDT) and drug challenges for milder reactions. Patch and IDT are, in general, performed no sooner than 4-6 weeks after resolution of the acute reaction at the maximum non-irritating concentrations. Functional in vitro and ex vivo assays have largely remained the province of research laboratories and include lymphocyte transformation test (LTT) and cytokine release enzyme linked ImmunoSpot (ELISpot) assay, an emerging diagnostic tool which uses cytokine release, typically IFN-γ, after the patient's peripheral blood mononuclear cells are stimulated with the suspected drug(s). Genetic markers such as human leukocyte antigen have shown recent promise for both pre-prescription screening as well as pre-emptive and diagnostic testing strategies.en_US
dc.language.isoeng-
dc.subjectHLAen_US
dc.subjectT cellsen_US
dc.subjectdelayed hypersensitivity reactionen_US
dc.subjectdrug allergyen_US
dc.subjectenzyme linked ImmunoSpot (ELISpot)en_US
dc.subjectlymphocyte transformation test (LTT)en_US
dc.subjectsevere cutaneous adverse reactionsen_US
dc.subjectskin testingen_US
dc.titleAn Updated Review of the Diagnostic Methods in Delayed Drug Hypersensitivity.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleFrontiers in Pharmacologyen_US
dc.identifier.affiliationClinical Immunology and Allergy, McGill University Health Center, Montréal, Canadaen_US
dc.identifier.affiliationDepartment of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, United Statesen_US
dc.identifier.affiliationThe National Center for Infections in Cancer, Peter MacCallum Cancer Center, Melbourne, VIC, Australiaen_US
dc.identifier.affiliationImmunology and Infectious Diseases, Murdoch University, Murdoch, WA, Australiaen_US
dc.identifier.affiliationInstitute for Immunology and Infectious Diseases, Murdoch University, Murdoch, WA, Australiaen_US
dc.identifier.affiliationInfectious Diseasesen_US
dc.identifier.affiliationDepartment of Oncology, Sir Peter MacCallum Cancer Center, The University of Melbourne, Parkville, VIC, Australiaen_US
dc.identifier.affiliationMedicine (University of Melbourne)en_US
dc.identifier.affiliationCentre for Antibiotic Allergy and Researchen_US
dc.identifier.doi10.3389/fphar.2020.573573en_US
dc.type.contentTexten_US
dc.identifier.pubmedid33597867-
local.name.researcherCopaescu, Ana-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptInfectious Diseases-
crisitem.author.deptInfectious Diseases-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptCentre for Antibiotic Allergy and Research-
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