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Title: What is T+? A Gordian Knot of Tracers, Thresholds & Topographies.
Austin Authors: Villemagne, Victor L ;Lopresti, Brian J;Doré, Vincent ;Tudorascu, Dana;Ikonomovic, Milos D;Burnham, Samantha;Minhas, Davneet;Pascoal, Tharick A;Mason, N Scott;Snitz, Beth;Aizenstein, Howard;Mathis, Chester A;Lopez, Oscar;Rowe, Christopher C ;Klunk, William E;Cohen, Ann D
Affiliation: Department of Psychiatry, University of Pittsburgh, United States
Department of Radiology, University of Pittsburgh School of Medicine
Department of Neurology, University of Pittsburgh School of Medicine
CSIRO Health & Biosecurity, Melbourne, Victoria, Australia
Molecular Imaging and Therapy
Issue Date: 31-Dec-2020 2020-12-31
Publication information: Journal of Nuclear Medicine 2020; online first: 29 December
Abstract: In this review we examine, in the context of the AT(N) framework, the available evidence as well as the potential alternatives on how to establish tau-positivity (T+) for multiple tau imaging tracers in order to come to a consensus for "normal" and "abnormal" tau imaging values that can be universally implemented in clinical research and therapeutic trials.
DOI: 10.2967/jnumed.120.245423
PubMed URL: 33384320
Type: Journal Article
Subjects: AT(N) framework
Alzheimer s disease
Molecular Imaging
Tau imaging
brain imaging
Appears in Collections:Journal articles

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