What is T+? A Gordian Knot of Tracers, Thresholds & Topographies.

Villemagne, Victor L; Lopresti, Brian J; Doré, Vincent; Tudorascu, Dana; Ikonomovic, Milos D; Burnham, Samantha; Minhas, Davneet; Pascoal, Tharick A; Mason, N Scott; Snitz, Beth; Aizenstein, Howard; Mathis, Chester A; Lopez, Oscar; Rowe, Christopher C; Klunk, William E; Cohen, Ann D

doi:10.2967/jnumed.120.245423

Title

What is T+? A Gordian Knot of Tracers, Thresholds & Topographies.

Publication Date

2020-12-31

Author(s)

Villemagne, Victor L

Lopresti, Brian J

Doré, Vincent

Tudorascu, Dana

Ikonomovic, Milos D

Burnham, Samantha

Minhas, Davneet

Pascoal, Tharick A

Mason, N Scott

Snitz, Beth

Aizenstein, Howard

Mathis, Chester A

Lopez, Oscar

Rowe, Christopher C

Klunk, William E

Cohen, Ann D

Subject

AT(N) framework

Alzheimer s disease

Biomarkers

Molecular Imaging

Neurology

PET

Tau imaging

brain imaging

Type of document

Journal Article

DOI

10.2967/jnumed.120.245423

Abstract

In this review we examine, in the context of the AT(N) framework, the available evidence as well as the potential alternatives on how to establish tau-positivity (T+) for multiple tau imaging tracers in order to come to a consensus for "normal" and "abnormal" tau imaging values that can be universally implemented in clinical research and therapeutic trials.

Link

link

Citation

Journal of Nuclear Medicine 2020; online first: 29 December

Jornal Title

Journal of Nuclear Medicine

Austin Health

Files: