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|Title:||Is poor self-rated sleep quality associated with elevated systemic inflammation in healthy older adults?||Austin Authors:||Petrov, Kimberley Kira;Hayley, Amie C ;Catchlove, Sarah;Savage, Karen;Stough, Con||Affiliation:||Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, Australia
Institute for Breathing and Sleep
|Issue Date:||Dec-2020||metadata.dc.date:||2020-10-17||Publication information:||Mechanisms of Ageing and Development 2020; 192: 111388||Abstract:||Examine subjective sleep quality and inflammation among healthy older adults participating in the Australian Research Council Longevity Intervention (ARCLI). Data was taken from a sub-set of 232 participants aged between 60-70 years (M = 65.88 ± SD 4.08 years) who participated in the baseline assessment phase of the Australian Research Council Longevity Intervention (ARCLI) study. Subjective sleep was assessed via the Leeds Sleep Evaluation Questionnaire (LSEQ). Inflammatory markers (TNF-α, IL-1β, IL-6, IL-10, IL-2, IFN-γ, IL-4, hs-CRP) were derived from whole blood. Correlation and multiple regression analyses were used to examine associations between each of the four sleep outcome variables and inflammatory outcomes, examined as a group and following gender stratification. Difficulties getting to sleep were independently associated with higher IL-2 [F(1,156) = 4.62, adjusted R2 = 0.02, p = 0.03] and IL-1β [F(1,141) = 8.52, adjusted R2 = 0.05, p = 0.004] (whole group). Difficulties getting to sleep were associated with greater IL-1β [males: F(1,58) = 7.36, adjusted R2 = 0.097 p = 0.009; females: F (1,81) = 4.25, R2 = 0.038, p = 0.04], and negatively associated with hs-CRP (women) [F (1,129) = 4.71, R2 = 0.028, p = 0.032]. Subjective sleep-onset difficulties are associated with systemic inflammation.||URI:||https://ahro.austin.org.au/austinjspui/handle/1/25138||DOI:||10.1016/j.mad.2020.111388||Journal:||Mechanisms of Ageing and Development||PubMed URL:||33080282||Type:||Journal Article||Subjects:||Ageing
|Appears in Collections:||Journal articles|
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