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dc.contributor.authorMedara, Nidhi-
dc.contributor.authorLenzo, Jason C-
dc.contributor.authorWalsh, Katrina A-
dc.contributor.authorDarby, Ivan B-
dc.contributor.authorO'Brien-Simpson, Neil M-
dc.contributor.authorReynolds, Eric C-
dc.identifier.citationCytokine 2020; 134: 155186-
dc.description.abstractT helper (Th)17 cells are implicated in the pathogenesis of periodontitis. This study investigated the effect of periodontal management on fifteen Th17-related cytokines in serum and saliva in periodontitis patients. Periodontal parameters, serum and saliva were collected from 40 healthy controls and 54 periodontitis subjects before treatment, and 3-, 6- and 12-months post-treatment. Cytokine concentrations of IL-1β, IL-4, IL-6, IL-10, IL-17A, IL-17F, IL-21, IL-22, IL-23, IL-25, IL-31, IL-33, IFN-γ, sCD40L and TNF-α were determined by Luminex assay. IL-1β, IL-6, sCD40L and TNF-α in serum, and IL-1β, IL-6, IL-25 and IL-31 in saliva were significantly higher at baseline compared to health and decreased with treatment. In contrast, serum IL-31 was significantly lower at baseline compared to health and increased with treatment. In addition, salivary IL-10, IL-17A, IL-17F, IL-23, IL-33, IFN-γ and TNF-α also displayed treatment-related reduction. Correlation networks showed that cytokines in saliva displayed a higher number of correlations compared to serum in periodontitis. Treatment generally decreased cytokine concentrations except for serum IL-31 which showed a treatment-related increase. Serum cytokine concentrations may not be reflective of salivary cytokines. Saliva may be a better medium for cytokine detection compared to serum. Serum IL-31 and salivary IL-1β, IL-6, IL-10 and TNF-α were significant predictors for mean probing depth and may be potential biomarkers of interest in the pathogenesis of periodontitis.-
dc.subjectPeriodontal debridement-
dc.titleT helper 17 cell-related cytokines in serum and saliva during management of periodontitis.-
dc.typeJournal Article-
dc.identifier.affiliationMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australiaen
dc.identifier.affiliationCentre for Oral Health Research, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australiaen
dc.identifier.affiliationAustin Health, Heidelberg, Victoria, Australiaen
dc.type.austinJournal Article-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
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