Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/23800
Full metadata record
DC FieldValueLanguage
dc.contributor.authorUng, David-
dc.contributor.authorDalli, Lachlan L-
dc.contributor.authorLopez, Derrick-
dc.contributor.authorSanfilippo, Frank M-
dc.contributor.authorKim, Joosup-
dc.contributor.authorAndrew, Nadine E-
dc.contributor.authorThrift, Amanda G-
dc.contributor.authorCadilhac, Dominique A-
dc.contributor.authorAnderson, Craig S-
dc.contributor.authorKilkenny, Monique F-
dc.date2020-07-08-
dc.date.accessioned2020-07-13T06:49:11Z-
dc.date.available2020-07-13T06:49:11Z-
dc.date.issued2021-03-
dc.identifier.citationBritish Journal of Clinical Pharmacology 2021; 87(3): 1089-1097-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/23800-
dc.description.abstractPrescribed daily dose (PDD), the number of doses prescribed to be taken per day, is used to calculate medication adherence using pharmacy claims data. PDD can be substituted by (1) 1 dose per day (1DD), (2) an estimate based on the 75th percentile of days taken by patients to refill a script (PDD75 ) or (3) the World Health Organisation's defined daily dose (DDD). We aimed to compare these approaches for estimating the duration covered by medications and whether this affects calculated 1-year adherence to antihypertensive medications post-stroke. We conducted a retrospective review of prospective cohort data from the ongoing Australian Stroke Clinical Registry linked with pharmacy claims data. Adherence was calculated as the proportion of days covered (PDC) for 1DD, PDD75 , and DDD. Differences were assessed using Wilcoxon rank-sum tests. Among 12628 eligible patients with stroke, 10057 (80%) were prescribed antihypertensive medications in the year after hospital discharge (78.2% aged ≥65 years, 45.2% female). Overall, the 75th percentile of patient time until next medication refill was 39 days. The greatest variations in dose regimens, estimated using person- and dose-level refill times, were for beta blockers (11.4% taking 2 tablets/day). There were comparable levels of adherence between 1DD and the PDD75 (median PDC 91.0% versus 91.2%; P=0.70), but adherence was slightly higher using DDD (92.3%; both P<0.001). However, this would represent a clinically non-significant difference. Adherence to antihypertensive medications shows similar estimates across standard measures of dosage in patients during the first year after an acute stroke.-
dc.language.isoeng-
dc.subjectantihypertensive agents-
dc.subjectcohort studies-
dc.subjectdatabases-
dc.subjectdrug prescriptions-
dc.subjectdrug utilization-
dc.subjecthypertension-
dc.subjectpharmacoepidemiology-
dc.subjectregistries-
dc.subjectsecondary prevention-
dc.subjectStroke-
dc.titleAssuming one dose per day yields a similar estimate of medication adherence in patients with stroke: an exploratory analysis using linked registry data.-
dc.typeJournal Article-
dc.identifier.journaltitleBritish Journal of Clinical Pharmacology-
dc.identifier.affiliationThe George Institute for Global Health Australia, Faculty of Medicine, The University of New South Wales, Sydney, New South Wales, Australiaen
dc.identifier.affiliationStroke Division, The Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationPeninsula Clinical School, Monash University, Frankston, Victoria, Australiaen
dc.identifier.affiliationNeurology Department, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australiaen
dc.identifier.affiliationThe George Institute for Global Health China at Peking University Health Science Center, Chinaen
dc.identifier.affiliationStroke and Ageing Research Group, Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australiaen
dc.identifier.affiliationSchool of Population and Global Health, The University of Western Australia, Perth, Western Australia, Australiaen
dc.identifier.doi10.1111/bcp.14468-
dc.identifier.orcid0000-0002-7931-6387-
dc.identifier.orcid0000-0003-3639-0787en
dc.identifier.orcid0000-0002-4079-0428en
dc.identifier.orcid0000-0001-8162-682Xen
dc.identifier.orcid0000-0002-3375-287Xen
dc.identifier.pubmedid32643250-
dc.type.austinJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

12
checked on Mar 28, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.