Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/23768
Title: Glycocalyx damage biomarkers in healthy controls, abdominal surgery, and abdominal surgery sepsis: a scoping review.
Austin Authors: Yanase, Fumitaka ;Naorungroj, Thummaporn ;Bellomo, Rinaldo 
Affiliation: Department of Intensive Care, Austin Health, Heidelberg, Victoria, Australia
Department of Medicine & Radiology, Centre for Integrated Critical Care, University of Melbourne, Melbourne, Australia
Australian and New Zealand Intensive Care Research Centre, Monash University School of Public Health and Preventive Medicine, Melbourne, Australia
Department of Intensive Care, Siriraj Hospital, Mahidol University, Bangkok, Thailand
Issue Date: 4-Jul-2020
Date: 2020-07-04
Publication information: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2020; online first: 4 July
Abstract: Objective: Despite wide interest in glycocalyx biomarkers, their values in healthy individuals, patients after abdominal surgery, and septic patients have been poorly understood.Methods: We searched MEDLINE, CENTRAL and EMBASE for papers measured glycocalyx biomarkers in healthy individuals, patients after abdominal surgery and septic patients.Results: We extracted 3948 titles and identified 58 eligible papers. Syndecan 1 was the most frequently measured biomarker (48 studies). Its mean or median value in healthy individuals varied to a biologically implausible degree, from 0.3 to 58.5 ng/ml, according to assay manufacturer. In post-operative patients, syndecan 1 levels increased after pancreatic surgery or liver surgery, however, they showed minor changes after hysterectomy or laparoscopic surgery. In septic patients, biomarker levels were higher than in healthy volunteers when using the same assay. However, six healthy volunteer studies reported higher syndecan 1 values than after pancreatic surgery and 24 healthy volunteer studies reported higher syndecan 1 values than the lowest syndecan 1 value in sepsis. Similar findings applied to other glycocalyx biomarkers.Conclusion: Glycocalyx damage biomarkers values are essentially defined by syndecan 1. Syndecan 1 levels, however, are markedly affected by assay type and show biologically implausible values in normal, post-operative, or septic subjects.
URI: https://ahro.austin.org.au/austinjspui/handle/1/23768
DOI: 10.1080/1354750X.2020.1787518
ORCID: 0000-0002-1650-8939
0000-0003-3859-3537
Journal: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
PubMed URL: 32597227
Type: Journal Article
Subjects: Glycocalyx
abdominal surgery
healthy volunteer
sepsis
syndecan 1
Appears in Collections:Journal articles

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