Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/23759
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dc.contributor.authorKhalilidehkordi, Elham-
dc.contributor.authorClarke, Laura-
dc.contributor.authorArnett, Simon-
dc.contributor.authorBukhari, Wajih-
dc.contributor.authorJimenez Sanchez, Sofia-
dc.contributor.authorO'Gorman, Cullen-
dc.contributor.authorSun, Jing-
dc.contributor.authorPrain, Kerri M-
dc.contributor.authorWoodhall, Mark-
dc.contributor.authorSilvestrini, Roger-
dc.contributor.authorBundell, Christine S-
dc.contributor.authorAbernethy, David-
dc.contributor.authorBhuta, Sandeep-
dc.contributor.authorBlum, Stefan-
dc.contributor.authorBoggild, Mike-
dc.contributor.authorBoundy, Karyn-
dc.contributor.authorBrew, Bruce J-
dc.contributor.authorBrown, Matthew-
dc.contributor.authorBrownlee, Wallace-
dc.contributor.authorButzkueven, Helmut-
dc.contributor.authorCarroll, William M-
dc.contributor.authorChen, Celia-
dc.contributor.authorCoulthard, Alan-
dc.contributor.authorDale, Russell C-
dc.contributor.authorDas, Chandi-
dc.contributor.authorFabis-Pedrini, Marzena J-
dc.contributor.authorFulcher, David-
dc.contributor.authorGillis, David-
dc.contributor.authorHawke, Simon-
dc.contributor.authorHeard, Robert-
dc.contributor.authorHenderson, Andrew P D-
dc.contributor.authorHeshmat, Saman-
dc.contributor.authorHodgkinson, Suzanne-
dc.contributor.authorKilpatrick, Trevor J-
dc.contributor.authorKing, John-
dc.contributor.authorKneebone, Chris-
dc.contributor.authorKornberg, Andrew J-
dc.contributor.authorLechner-Scott, Jeannette-
dc.contributor.authorLin, Ming-Wei-
dc.contributor.authorLynch, Christopher-
dc.contributor.authorMacdonell, Richard A L-
dc.contributor.authorMason, Deborah F-
dc.contributor.authorMcCombe, Pamela A-
dc.contributor.authorPereira, Jennifer-
dc.contributor.authorPollard, John D-
dc.contributor.authorRamanathan, Sudarshini-
dc.contributor.authorReddel, Stephen W-
dc.contributor.authorShaw, Cameron-
dc.contributor.authorSpies, Judith-
dc.contributor.authorStankovich, James-
dc.contributor.authorSutton, Ian-
dc.contributor.authorVucic, Steve-
dc.contributor.authorWalsh, Michael-
dc.contributor.authorWong, Richard C-
dc.contributor.authorYiu, Eppie M-
dc.contributor.authorBarnett, Michael H-
dc.contributor.authorKermode, Allan G-
dc.contributor.authorMarriott, Mark P-
dc.contributor.authorParratt, John-
dc.contributor.authorSlee, Mark-
dc.contributor.authorTaylor, Bruce V-
dc.contributor.authorWilloughby, Ernest-
dc.contributor.authorBrilot, Fabienne-
dc.contributor.authorVincent, Angela-
dc.contributor.authorWaters, Patrick-
dc.contributor.authorBroadley, Simon A-
dc.date2020-
dc.date.accessioned2020-07-06T06:53:46Z-
dc.date.available2020-07-06T06:53:46Z-
dc.date.issued2020-
dc.identifier.citationFrontiers in neurology 2020; 11: 537-
dc.identifier.issn1664-2295-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/23759-
dc.description.abstractNeuromyelitis optica spectrum disorders (NMOSD) and multiple sclerosis (MS) show overlap in their clinical features. We performed an analysis of relapses with the aim of determining differences between the two conditions. Cases of NMOSD and age- and sex-matched MS controls were collected from across Australia and New Zealand. Demographic and clinical information, including relapse histories, were recorded using a standard questionnaire. There were 75 cases of NMOSD and 101 MS controls. There were 328 relapses in the NMOSD cases and 375 in MS controls. Spinal cord and optic neuritis attacks were the most common relapses in both NMOSD and MS. Optic neuritis (p < 0.001) and area postrema relapses (P = 0.002) were more common in NMOSD and other brainstem attacks were more common in MS (p < 0.001). Prior to age 30 years, attacks of optic neuritis were more common in NMOSD than transverse myelitis. After 30 this pattern was reversed. Relapses in NMOSD were more likely to be treated with acute immunotherapies and were less likely to recover completely. Analysis by month of relapse in NMOSD showed a trend toward reduced risk of relapse in February to April compared to a peak in November to January (P = 0.065). Optic neuritis and transverse myelitis are the most common types of relapse in NMOSD and MS. Optic neuritis tends to occur more frequently in NMOSD prior to the age of 30, with transverse myelitis being more common thereafter. Relapses in NMOSD were more severe. A seasonal bias for relapses in spring-summer may exist in NMOSD.-
dc.language.isoeng-
dc.subjectaquaporin-
dc.subjectepidemiology-
dc.subjectmultiple sclerosis-
dc.subjectneuromyelitis optica-
dc.subjectrelapse-
dc.subjectseasonality-
dc.titleRelapse Patterns in NMOSD: Evidence for Earlier Occurrence of Optic Neuritis and Possible Seasonal Variation.-
dc.typeJournal Article-
dc.identifier.journaltitleFrontiers in neurology-
dc.identifier.affiliationFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australiaen
dc.identifier.affiliationDepartment of Neurology, Royal Adelaide Hospital, Adelaide, SA, Australiaen
dc.identifier.affiliationHunter Medical Research Institute, University of Newcastle, Callaghan, NSW, Australiaen
dc.identifier.affiliationCentre for Clinical Research, Royal Brisbane and Women's Hospital, University of Queensland, Herston, QLD, Australiaen
dc.identifier.affiliationDepartment of Neurology, Westmead Hospital, Westmead, NSW, Australiaen
dc.identifier.affiliationSchool of Medicine, Deakin University, Waurn Ponds, VIC, Australiaen
dc.identifier.affiliationDepartment of Neurology, St Vincent's Hospital, Darlinghurst, NSW, Australiaen
dc.identifier.affiliationWestmead Clinical School, Westmead Hospital, University of Sydney, Westmead, NSW, Australiaen
dc.identifier.affiliationDepartment of Neurology, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationDivision of Immunology, HSQ Pathology Queensland Central Laboratory, Herston, QLD, Australiaen
dc.identifier.affiliationSchool of Paediatrics, Royal Children's Hospital, University of Melbourne, Parkville, VIC, Australiaen
dc.identifier.affiliationBrain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australiaen
dc.identifier.affiliationCentre for Neuromuscular and Neurological Disorders, Perron Institute for Neurological and Translational Science, Queen Elizabeth II Medical Centre, University of Western Australia, Nedlands, WA, Australiaen
dc.identifier.affiliationDepartment of Neurology, Princess Alexandra Hospital, Woolloongabba, QLD, Australiaen
dc.identifier.affiliationDepartment of Immunopathology, Westmead Hospital, Westmead, NSW, Australiaen
dc.identifier.affiliationSchool of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, WA, Australiaen
dc.identifier.affiliationDepartment of Neurology, Townsville University Hospital, Douglas, QLD, Australiaen
dc.identifier.affiliationPeter Duncan Neurosciences Unit, Centre for Applied Medical Research and Department of Neurology, St Vincent's Hospital, University of New South Wales, Darlinghurst, NSW, Australiaen
dc.identifier.affiliationInstitute of Health Biomedical Innovation, Translational Research Institute, Queensland University of Technology, Woolloongabba, QLD, Australiaen
dc.identifier.affiliationDepartment of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, Australiaen
dc.identifier.affiliationSchool of Medicine, Royal Brisbane and Women's Hospital, University of Queensland, Herston, QLD, Australiaen
dc.identifier.affiliationDepartment of Neurology, Canberra Hospital, Garran, ACT, Australiaen
dc.identifier.affiliationSouth Western Sydney Medical School, Liverpool Hospital, University of New South Wales, Liverpool, NSW, Australiaen
dc.identifier.affiliationDepartment of Neurology, Royal Melbourne Hospital, Parkville, VIC, Australiaen
dc.identifier.affiliationSydney Medical School, Royal Prince Alfred Hospital, University of Sydney, Camperdown, NSW, Australiaen
dc.identifier.affiliationFlinders Medical Centre, Flinders University, Bedford Park, SA, Australiaen
dc.identifier.affiliationMenzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australiaen
dc.identifier.affiliationBrain Autoimmunity Group, Institute for Neuroscience and Muscle Research, The Kids Research Institute at the Children's Hospital, Westmead, NSW, Australiaen
dc.identifier.affiliationMenzies Health Institute Queensland, Gold Coast Campus, Griffith University, Southport, QLD, Australiaen
dc.identifier.affiliationNuffield Department of Clinical Neurosciences, John Radcliffe Infirmary, University of Oxford, Oxford, United Kingdom-
dc.identifier.affiliationDepartment of Neurology, Wellington Hospital, Newtown, United Kingdom-
dc.identifier.affiliationDepartment of Neurology, Auckland City Hospital, Grafton, New Zealand-
dc.identifier.affiliationSchool of Medicine, University of Auckland, Grafton, New Zealand-
dc.identifier.affiliationDepartment of Neurology, Christchurch Hospital, Christchurch, New Zealand-
dc.identifier.affiliationSchool of Medicine, University of Auckland, Grafton, New Zealand-
dc.identifier.affiliationDepartment of Neurology, Auckland City Hospital, Grafton, New Zealand-
dc.identifier.affiliationNuffield Department of Clinical Neurosciences, John Radcliffe Infirmary, University of Oxford, Oxford, United Kingdom-
dc.identifier.doi10.3389/fneur.2020.00537-
dc.identifier.pubmedid32612571-
dc.type.austinJournal Article-
local.name.researcherMacdonell, Richard A L
item.grantfulltextnone-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
crisitem.author.deptNeurology-
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