Austin Health

Title
Relapse Patterns in NMOSD: Evidence for Earlier Occurrence of Optic Neuritis and Possible Seasonal Variation.
Publication Date
2020
Author(s)
Khalilidehkordi, Elham
Clarke, Laura
Arnett, Simon
Bukhari, Wajih
Jimenez Sanchez, Sofia
O'Gorman, Cullen
Sun, Jing
Prain, Kerri M
Woodhall, Mark
Silvestrini, Roger
Bundell, Christine S
Abernethy, David
Bhuta, Sandeep
Blum, Stefan
Boggild, Mike
Boundy, Karyn
Brew, Bruce J
Brown, Matthew
Brownlee, Wallace
Butzkueven, Helmut
Carroll, William M
Chen, Celia
Coulthard, Alan
Dale, Russell C
Das, Chandi
Fabis-Pedrini, Marzena J
Fulcher, David
Gillis, David
Hawke, Simon
Heard, Robert
Henderson, Andrew P D
Heshmat, Saman
Hodgkinson, Suzanne
Kilpatrick, Trevor J
King, John
Kneebone, Chris
Kornberg, Andrew J
Lechner-Scott, Jeannette
Lin, Ming-Wei
Lynch, Christopher
Macdonell, Richard A L
Mason, Deborah F
McCombe, Pamela A
Pereira, Jennifer
Pollard, John D
Ramanathan, Sudarshini
Reddel, Stephen W
Shaw, Cameron
Spies, Judith
Stankovich, James
Sutton, Ian
Vucic, Steve
Walsh, Michael
Wong, Richard C
Yiu, Eppie M
Barnett, Michael H
Kermode, Allan G
Marriott, Mark P
Parratt, John
Slee, Mark
Taylor, Bruce V
Willoughby, Ernest
Brilot, Fabienne
Vincent, Angela
Waters, Patrick
Broadley, Simon A
Subject
aquaporin
epidemiology
multiple sclerosis
neuromyelitis optica
relapse
seasonality
Type of document
Journal Article
DOI
10.3389/fneur.2020.00537
Abstract
Neuromyelitis optica spectrum disorders (NMOSD) and multiple sclerosis (MS) show overlap in their clinical features. We performed an analysis of relapses with the aim of determining differences between the two conditions. Cases of NMOSD and age- and sex-matched MS controls were collected from across Australia and New Zealand. Demographic and clinical information, including relapse histories, were recorded using a standard questionnaire. There were 75 cases of NMOSD and 101 MS controls. There were 328 relapses in the NMOSD cases and 375 in MS controls. Spinal cord and optic neuritis attacks were the most common relapses in both NMOSD and MS. Optic neuritis (p < 0.001) and area postrema relapses (P = 0.002) were more common in NMOSD and other brainstem attacks were more common in MS (p < 0.001). Prior to age 30 years, attacks of optic neuritis were more common in NMOSD than transverse myelitis. After 30 this pattern was reversed. Relapses in NMOSD were more likely to be treated with acute immunotherapies and were less likely to recover completely. Analysis by month of relapse in NMOSD showed a trend toward reduced risk of relapse in February to April compared to a peak in November to January (P = 0.065). Optic neuritis and transverse myelitis are the most common types of relapse in NMOSD and MS. Optic neuritis tends to occur more frequently in NMOSD prior to the age of 30, with transverse myelitis being more common thereafter. Relapses in NMOSD were more severe. A seasonal bias for relapses in spring-summer may exist in NMOSD.
Link
Citation
Frontiers in neurology 2020; 11: 537
Jornal Title
Frontiers in neurology
ISSN
1664-2295

Files:

NameSizeformatDescriptionLink