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https://ahro.austin.org.au/austinjspui/handle/1/22307
Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Foo, Chee Yoong | - |
dc.contributor.author | Andrianopoulos, Nick | - |
dc.contributor.author | Brennan, Angela | - |
dc.contributor.author | Ajani, Andrew | - |
dc.contributor.author | Reid, Christopher M | - |
dc.contributor.author | Duffy, Stephen J | - |
dc.contributor.author | Clark, David J | - |
dc.contributor.author | Reidpath, Daniel D | - |
dc.contributor.author | Chaiyakunapruk, Nathorn | - |
dc.date | 2019-12-27 | - |
dc.date.accessioned | 2020-01-07T00:33:30Z | - |
dc.date.available | 2020-01-07T00:33:30Z | - |
dc.date.issued | 2019-12-27 | - |
dc.identifier.citation | Scientific Reports 2019; 9(1): 19978 | en_US |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/22307 | - |
dc.description.abstract | Literature studying the door-to-balloon time-outcome relation in coronary intervention is limited by the potential of residual biases from unobserved confounders. This study re-examines the time-outcome relation with further consideration of the unobserved factors and reports the population average effect. Adults with ST-elevation myocardial infarction admitted to one of the six registry participating hospitals in Australia were included in this study. The exposure variable was patient-level door-to-balloon time. Primary outcomes assessed included in-hospital and 30 days mortality. 4343 patients fulfilled the study criteria. 38.0% (1651) experienced a door-to-balloon delay of >90 minutes. The absolute risk differences for in-hospital and 30-day deaths between the two exposure subgroups with balanced covariates were 2.81 (95% CI 1.04, 4.58) and 3.37 (95% CI 1.49, 5.26) per 100 population. When unmeasured factors were taken into consideration, the risk difference were 20.7 (95% CI -2.6, 44.0) and 22.6 (95% CI -1.7, 47.0) per 100 population. Despite further adjustment of the observed and unobserved factors, this study suggests a directionally consistent linkage between longer door-to-balloon delay and higher risk of adverse outcomes at the population level. Greater uncertainties were observed when unmeasured factors were taken into consideration. | en_US |
dc.language.iso | eng | - |
dc.title | Re-examining the effect of door-to-balloon delay on STEMI outcomes in the context of unmeasured confounders: a retrospective cohort study. | en_US |
dc.type | Journal Article | en_US |
dc.identifier.journaltitle | Scientific Reports | en_US |
dc.identifier.affiliation | Cardiology | en_US |
dc.identifier.affiliation | Centre of Cardiovascular Research & Education in Therapeutics, Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia | en_US |
dc.identifier.affiliation | Department of Cardiology, Alfred Hospital, Melbourne, Australia | en_US |
dc.identifier.affiliation | Department of Cardiology, Royal Melbourne Hospital, Melbourne, Australia | en_US |
dc.identifier.affiliation | Department of Medicine, University of Melbourne, Melbourne, Australia | en_US |
dc.identifier.affiliation | Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Selangor, Malaysia | en_US |
dc.identifier.affiliation | School of Public Health, Curtin University, Perth, WA, Australia | en_US |
dc.identifier.affiliation | Molecular, Genetic & Population Health Sciences, University of Edinburgh, Edinburgh, UK | en_US |
dc.identifier.affiliation | National Clinical Research Centre, Kuala Lumpur, Malaysia | en_US |
dc.identifier.affiliation | School of Pharmacy, Monash University Malaysia, Bandar Sunway, Selangor, Malaysia | en_US |
dc.identifier.affiliation | Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Selangor, Malaysia | en_US |
dc.identifier.affiliation | Department of Pharmacotherapy, College of Pharmacy, The University of Utah, Salt Lake City, UT, USA | en_US |
dc.identifier.doi | 10.1038/s41598-019-56353-7 | en_US |
dc.type.content | Text | en_US |
dc.identifier.orcid | 0000-0002-1833-4290 | en_US |
dc.identifier.pubmedid | 31882674 | - |
dc.type.austin | Journal Article | - |
local.name.researcher | Clark, David J | |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.openairetype | Journal Article | - |
crisitem.author.dept | Cardiology | - |
crisitem.author.dept | University of Melbourne Clinical School | - |
Appears in Collections: | Journal articles |
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