Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/22307
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dc.contributor.authorFoo, Chee Yoong-
dc.contributor.authorAndrianopoulos, Nick-
dc.contributor.authorBrennan, Angela-
dc.contributor.authorAjani, Andrew-
dc.contributor.authorReid, Christopher M-
dc.contributor.authorDuffy, Stephen J-
dc.contributor.authorClark, David J-
dc.contributor.authorReidpath, Daniel D-
dc.contributor.authorChaiyakunapruk, Nathorn-
dc.date2019-12-27-
dc.date.accessioned2020-01-07T00:33:30Z-
dc.date.available2020-01-07T00:33:30Z-
dc.date.issued2019-12-27-
dc.identifier.citationScientific Reports 2019; 9(1): 19978en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/22307-
dc.description.abstractLiterature studying the door-to-balloon time-outcome relation in coronary intervention is limited by the potential of residual biases from unobserved confounders. This study re-examines the time-outcome relation with further consideration of the unobserved factors and reports the population average effect. Adults with ST-elevation myocardial infarction admitted to one of the six registry participating hospitals in Australia were included in this study. The exposure variable was patient-level door-to-balloon time. Primary outcomes assessed included in-hospital and 30 days mortality. 4343 patients fulfilled the study criteria. 38.0% (1651) experienced a door-to-balloon delay of >90 minutes. The absolute risk differences for in-hospital and 30-day deaths between the two exposure subgroups with balanced covariates were 2.81 (95% CI 1.04, 4.58) and 3.37 (95% CI 1.49, 5.26) per 100 population. When unmeasured factors were taken into consideration, the risk difference were 20.7 (95% CI -2.6, 44.0) and 22.6 (95% CI -1.7, 47.0) per 100 population. Despite further adjustment of the observed and unobserved factors, this study suggests a directionally consistent linkage between longer door-to-balloon delay and higher risk of adverse outcomes at the population level. Greater uncertainties were observed when unmeasured factors were taken into consideration.en_US
dc.language.isoeng-
dc.titleRe-examining the effect of door-to-balloon delay on STEMI outcomes in the context of unmeasured confounders: a retrospective cohort study.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleScientific Reportsen_US
dc.identifier.affiliationCardiologyen_US
dc.identifier.affiliationCentre of Cardiovascular Research & Education in Therapeutics, Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australiaen_US
dc.identifier.affiliationDepartment of Cardiology, Alfred Hospital, Melbourne, Australiaen_US
dc.identifier.affiliationDepartment of Cardiology, Royal Melbourne Hospital, Melbourne, Australiaen_US
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Melbourne, Australiaen_US
dc.identifier.affiliationJeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Selangor, Malaysiaen_US
dc.identifier.affiliationSchool of Public Health, Curtin University, Perth, WA, Australiaen_US
dc.identifier.affiliationMolecular, Genetic & Population Health Sciences, University of Edinburgh, Edinburgh, UKen_US
dc.identifier.affiliationNational Clinical Research Centre, Kuala Lumpur, Malaysiaen_US
dc.identifier.affiliationSchool of Pharmacy, Monash University Malaysia, Bandar Sunway, Selangor, Malaysiaen_US
dc.identifier.affiliationJeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Selangor, Malaysiaen_US
dc.identifier.affiliationDepartment of Pharmacotherapy, College of Pharmacy, The University of Utah, Salt Lake City, UT, USAen_US
dc.identifier.doi10.1038/s41598-019-56353-7en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0002-1833-4290en_US
dc.identifier.pubmedid31882674-
dc.type.austinJournal Article-
local.name.researcherClark, David J
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptCardiology-
crisitem.author.deptUniversity of Melbourne Clinical School-
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