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dc.contributor.authorRaghu, Dinesh-
dc.contributor.authorXue, Hai-Hui-
dc.contributor.authorMielke, Lisa A-
dc.identifier.citationTrends in immunology 2019; 40(12): 1149-1162-
dc.description.abstractT cell factor-1 (TCF-1), encoded by Tcf7, is a transcription factor and histone deacetylase (HDAC) essential for commitment to both the T cell and the innate lymphoid cell (ILC) lineages in mammals. In this review, we discuss the multifunctional role of TCF-1 in establishing these lineages and the requirement for TCF-1 throughout lineage differentiation and maintenance of lineage stability. We highlight recent reports showing promise for TCF-1 as a novel biomarker to identify recently characterized subsets of exhausted CD8+ T cells that may help to predict patient responses to immune checkpoint blockade (ICB).-
dc.subjectT cell-
dc.subjectT cell factor-1-
dc.subjectinnate lymphoid cell-
dc.subjectstem cell-like memory-
dc.subjecttranscription factor-
dc.titleControl of Lymphocyte Fate, Infection, and Tumor Immunity by TCF-1.-
dc.typeJournal Article-
dc.identifier.journaltitleTrends in immunology-
dc.identifier.affiliationIowa City Veterans Affairs Health Care System, Iowa City, IA 52246, USAen
dc.identifier.affiliationSchool of Cancer Medicine, LaTrobe University, Heidelberg, VIC 3084, Australiaen
dc.identifier.affiliationDepartment of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USAen
dc.identifier.affiliationSchool of Molecular Sciences, College of Science, Health and Engineering, LaTrobe University, Bundoora, VIC 3083, Australiaen
dc.identifier.affiliationCancer Immunobiology Program, Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australiaen
dc.type.austinJournal Article-
Appears in Collections:Journal articles
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