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Title: Control of Lymphocyte Fate, Infection, and Tumor Immunity by TCF-1.
Austin Authors: Raghu, Dinesh;Xue, Hai-Hui;Mielke, Lisa A
Affiliation: Iowa City Veterans Affairs Health Care System, Iowa City, IA 52246, USA
School of Cancer Medicine, LaTrobe University, Heidelberg, VIC 3084, Australia
Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
School of Molecular Sciences, College of Science, Health and Engineering, LaTrobe University, Bundoora, VIC 3083, Australia
Cancer Immunobiology Program, Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia
Issue Date: Dec-2019 2019-12
Publication information: Trends in immunology 2019; 40(12): 1149-1162
Abstract: T cell factor-1 (TCF-1), encoded by Tcf7, is a transcription factor and histone deacetylase (HDAC) essential for commitment to both the T cell and the innate lymphoid cell (ILC) lineages in mammals. In this review, we discuss the multifunctional role of TCF-1 in establishing these lineages and the requirement for TCF-1 throughout lineage differentiation and maintenance of lineage stability. We highlight recent reports showing promise for TCF-1 as a novel biomarker to identify recently characterized subsets of exhausted CD8+ T cells that may help to predict patient responses to immune checkpoint blockade (ICB).
DOI: 10.1016/
ORCID: 0000-0002-8960-6222
PubMed URL: 31734149
Type: Journal Article
Subjects: T cell
T cell factor-1
innate lymphoid cell
stem cell-like memory
transcription factor
Appears in Collections:Journal articles

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