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Title: Bone mineral density response with denosumab in combination with standard or high-dose teriparatide: the DATA-HD RCT.
Austin Authors: Ramchand, Sabashini K ;David, Natalie L;Leder, Benjamin Z;Tsai, Joy N
Affiliation: Department of Medicine, Endocrine Unit, Massachusetts General Hospital,Harvard University, Boston, MA, USA
Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Issue Date: Mar-2020 2019-11-01
Publication information: The Journal of Clinical Endocrinology and Metabolism 2020; 105(3): 890-897
Abstract: In the DATA-HD study, we reported that 15-months of combined high-dose (HD) teriparatide and denosumab increased mean areal bone mineral density (aBMD) at the hip and spine more than combined denosumab and standard-dose teriparatide (SD). In the current analysis, we compare the individual rates of aBMD response between the treatment groups. Single-site, open-label, randomized controlled trial in which postmenopausal women received either teriparatide 20-μg daily (SD) or 40-μg daily (HD) given months 0-9, overlapped with denosumab 60-mg, given months 3-15 (15-month total duration). The proportion of participants in the SD and HD groups experiencing total hip, femoral neck, and lumbar spine aBMD gains of >3%, >6%, and >9% were compared. Postmenopausal women with osteoporosis completing all study visits (n = 60). aBMD (dual x-ray absorptiometry). At the end of the 15-month treatment period, a higher proportion of women in the HD group had BMD increases >3% (83% vs. 58%, P=0.037) and >6% (45% vs. 19%, P=0.034) at the total hip, and >3% at the femoral neck (86% vs. 63%, P=0.044). At the lumbar spine, >3% response rates were similar whereas the >6% and >9% response rates were greater in the HD group (100% vs. 79%, P=0.012 and 93% vs. 59%, P=0.003, respectively). Compared with the SD regimen, more women treated with the HD regimen achieved clinically meaningful and rapid gains in hip and spine aBMD. These results suggest that this approach may provide unique benefits in the treatment of postmenopausal osteoporosis.
DOI: 10.1210/clinem/dgz163
Journal: The Journal of Clinical Endocrinology and Metabolism
PubMed URL: 31674641
Type: Journal Article
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