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Title: Angiographic outcome of coronary artery bypass grafts: Radial Artery Database International Alliance.
Austin Authors: Gaudino, Mario;Benedetto, Umberto;Fremes, Stephen E;Hare, David L ;Hayward, Philip;Moat, Neil;Moscarelli, Marco;Di Franco, Antonino;Nasso, Giuseppe;Peric, Miodrag;Petrovic, Ivana;Collins, Peter;Webb, Carolyn M;Puskas, John D;Speziale, Giuseppe;Yoo, Kyung Jong;Girardi, Leonard N;Taggart, David P
Affiliation: Department of Cardiothoracic Surgery, Cornell Medicine, New York, US
Austin Health
University of Melbourne, Melbourne, Australia
Bristol Heart Institute, Bristol, UK
Schulich Heart Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada
Royal Brompton & Harefield Trust, London, UK
Anthea Hospital, Bari, Italy
Department of Cardiothoracic Surgery, Cornell Medicine, New York, US
Anthea Hospital, Bari, Italy
Dedinje Cardiovascular Institute and Belgrade University School of Medicine, Belgrade, Serbia
National Heart & Lung Institute, Imperial College London, London, UK
Icahn School of Medicine at Mount Sinai, New York City, US
Yonsei University College of Medicine, Seoul, Korea
Department of Cardiothoracic Surgery, Cornell Medicine, New York, US
University of Oxford, Oxford, UK
Issue Date: Mar-2020
Date: 2019-08-27
Publication information: The Annals of Thoracic Surgery 2020; 109(3): 688-694
Abstract: We used a large patient-level dataset including six angiographic randomized trials (RCTs) on coronary artery bypass conduits to explore incidence and determinants of coronary graft failure. Patient-level angiographic data of six RCTs comparing long-term outcomes of the radial artery and other conduits were joined. Primary outcome was graft occlusion at maximum follow-up. The analysis was divided as follows: 1) left anterior descending coronary (LAD) distribution, 2) non-LAD distribution (circumflex and right coronary artery). To identify predictors of graft occlusion, mixed model multivariable Cox regression including all baseline characteristics with stratification by individual trials was used. 1091 patients and 2281 grafts were included (921 left internal mammary arteries, 74 right internal mammary arteries, 710 radial artery and 576 saphenous veins; all left internal mammary arteries were used on the LAD, the other conduits were used on the non-LAD distribution; mean angiographic follow up: 65±29 months). Occlusion rate was 2.3%, 13.5%, 9.4%, 17.5% for the left internal mammary arteries, right internal mammary arteries, radial artery and saphenous veins, respectively. At multivariable analysis type of conduit used, age, female gender, left ventricular ejection fraction<50% and use of the Y graft were significantly associated with graft occlusion in the non-LAD distribution. Our analyses showed that failure of the left internal mammary arteries to LAD bypass is a very uncommon event. For the non-LAD distribution, the non-use of radial artery, age, female gender, left ventricular ejection fraction<50% and use of the Y graft configuration were significantly associated with mid-term graft failure.
DOI: 10.1016/j.athoracsur.2019.07.010
Journal: The Annals of Thoracic Surgery
PubMed URL: 31470012
Type: Journal Article
Subjects: CABG
radial artery
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