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Title: COMT val158met is not associated with Aβ-amyloid and APOE ε4 related cognitive decline in cognitively normal older adults.
Austin Authors: Porter, Tenielle;Burnham, Samantha C;Milicic, Lidija;Savage, Greg;Maruff, Paul;Sohrabi, Hamid R;Peretti, Madeline;Lim, Yen Ying;Weinborn, Michael;Ames, David;Masters, Colin L ;Martins, Ralph N;Rainey-Smith, Stephanie R;Rowe, Christopher C ;Salvado, Olivier;Groth, David;Verdile, Giuseppe;Villemagne, Victor L ;Laws, Simon M
Affiliation: Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup 6027, Western Australia, Australia
School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley 6102, Western Australia, Australia
Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia
National Ageing Research Institute, Parkville 3052, Victoria, Australia
Academic Unit for Psychiatry of Old Age, St. Vincent's Health, The University of Melbourne, Kew 3101, Victoria, Australia
School of Psychology, University of Western Australia, Crawley 6009, Western Australia, Australia
CogState Ltd., Melbourne 3000, Victoria, Australia
Collaborative Genomics Group, Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup 6027, Western Australia, Australia
CSIRO Health and Biosecurity/Australian e-Health Research Centre, Herston 4029, Queensland, Australia
CSIRO Health and Biosecurity, Parkville 3052, Victoria, Australia
The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville 3052, Victoria, Australia
ARC Centre of Excellence in Cognition and its Disorders, Department of Psychology, Macquarie University, North Ryde 2113, NSW, Australia
Cooperative Research Centre for Mental Health, Australia
Issue Date: Jun-2019
Date: 2019-05-02
Publication information: IBRO reports 2019; 6: 147-152
Abstract: The non-synonymous single nucleotide polymorphism (SNP), Val158Met within the Catechol-O-methyltransferase (COMT) gene has been associated with altered levels of cognition and memory performance in cognitively normal adults. This study aimed to investigate the independent and interactional effects of COMT Val158Met on cognitive performance. In particular, it was hypothesised that COMT Val158Met would modify the effect of neocortical Aβ-amyloid (Aβ) accumulation and carriage of the apolipoprotein E (APOE) ε4 allele on cognition in preclinical Alzheimer's disease (AD). In 598 cognitively normal older adults with known neocortical Aβ levels, linear mixed modelling revealed no significant independent or interactional associations between COMT Val158Met and cognitive decline. These findings do not support previous associations between COMT Val158Met and cognitive performance and suggest this variant does not influence Aβ-amyloid or APOE ε4 driven cognitive decline in a well characterised cohort of cognitively normal older adults.
DOI: 10.1016/j.ibror.2019.05.001
ORCID: 0000-0003-3910-2453
Journal: IBRO reports
PubMed URL: 31080907
Type: Journal Article
Subjects: Aβ-amyloid
Cognitive decline
Episodic memory
Appears in Collections:Journal articles

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