Please use this identifier to cite or link to this item:
Title: Occupational exposure to solvents and lung function decline: A population based study.
Austin Authors: Alif, Sheikh M;Dharmage, Shyamali;Benke, Geza;Dennekamp, Martine;Burgess, John;Perret, Jennifer L ;Lodge, Caroline;Morrison, Stephen;Johns, David Peter;Giles, Graham;Gurrin, Lyle;Thomas, Paul S;Hopper, John Llewelyn;Wood-Baker, Richard;Thompson, Bruce;Feather, Iain;Vermeulen, Roel;Kromhout, Hans;Jarvis, Debbie;Garcia Aymerich, Judith;Walters, E Haydn;Abramson, Michael J;Matheson, Melanie Claire
Affiliation: Environmental Epidemiology Division, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
National Heart and Lung Institute, Imperial College, London, United Kingdom of Great Britain and Northern Ireland
ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain
Environmental Public Health, Environment Protection Authority Victoria, Melbourne, Victoria, Australia
Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia
School of Medicine, University of Tasmania, Hobart, Tasmania, Australia
Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
Department of Respiratory and Sleep Medicine, Austin Health, Heidelberg, Victoria, Australia
Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Victoria, Australia
Medicine, Gold Coast University Hospital, Southport, Queensland, Australia
Health Sciences, Swinburne University of Technology, Melbourne, Victoria, Australia
Faculty of Medicine, University of new South Wales, Sydney, New South Wales, Australia
Department of Medicine, University of Queensland, Brisbane, Queensland, Australia
Issue Date: Jul-2019 2019-04-26
Publication information: Thorax 2019; 74(7): 650-686
Abstract: While cross-sectional studies have shown associations between certain occupational exposures and lower levels of lung function, there was little evidence from population-based studies with repeated lung function measurements. We aimed to investigate the associations between occupational exposures and longitudinal lung function decline in the population-based Tasmanian Longitudinal Health Study. Lung function decline between ages 45 years and 50 years was assessed using data from 767 participants. Using lifetime work history calendars completed at age 45 years, exposures were assigned according to the ALOHA plus Job Exposure Matrix. Occupational exposures were defined as ever exposed and cumulative exposure -unit- years. We investigated effect modification by sex, smoking and asthma status. Compared with those without exposure, ever exposures to aromatic solvents and metals were associated with a greater decline in FEV1 (aromatic solvents 15.5 mL/year (95% CI -24.8 to 6.3); metals 11.3 mL/year (95% CI -21.9 to - 0.7)) and FVC (aromatic solvents 14.1 mL/year 95% CI -28.8 to - 0.7; metals 17.5 mL/year (95% CI -34.3 to - 0.8)). Cumulative exposure (unit years) to aromatic solvents was also associated with greater decline in FEV1 and FVC. Women had lower cumulative exposure years to aromatic solvents than men (mean (SD) 9.6 (15.5) vs 16.6 (14.6)), but greater lung function decline than men. We also found association between ever exposures to gases/fumes or mineral dust and greater decline in lung function. Exposures to aromatic solvents and metals were associated with greater lung function decline. The effect of aromatic solvents was strongest in women. Preventive strategies should be implemented to reduce these exposures in the workplace.
DOI: 10.1136/thoraxjnl-2018-212267
ORCID: 0000-0002-0783-8848
Journal: Thorax
PubMed URL: 31028237
Type: Journal Article
Subjects: FEV1
chronic obstructive pulmonary disease
job exposure matrix
lung function
occupational exposure
Appears in Collections:Journal articles

Show full item record

Google ScholarTM


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.